DOK1
Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.Function
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia patients in the chronic phase. It may be a critical substrate for p210, a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 from CML cells. It has been postulated to play a role in mitogenic signaling.Interactions
DOK1 has been shown to interact with:
