DLG2


Disks large homolog 2 also known as channel-associated protein of synapse-110 or postsynaptic density protein 93 is a protein that in humans is encoded by the DLG2 gene.

Function

Chapsyn-110/PSD-93 a member of the membrane-associated guanylate kinase family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.

Model organisms

s have been used in the study of DLG2 function. A knockout mouse line, called Dlg2tm1Dsb was generated. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on homozygous mutant mice and five significant abnormalities were observed. Both sexes had atypical indirect calorimetry and DEXA parameters. Females also had decreased body weight, decreased circulating HDL cholesterol levels, and increased susceptibility to bacterial infection.

Interactions

DLG2 has been shown to interact with GRIN2B, KCNJ12.