Cytochrome P450 cam


Cytochrome P450 camphor 5-monooxygenase is a bacterial enzyme originally from Pseudomonas putida, which catalyzes a critical step in the metabolism of camphor. In 1987, Cytochrome P450cam was the first cytochrome P450 three-dimensional protein structure solved by X-ray crystallography.
It is a heterotrimeric protein derived from the products of three genes: a cytochrome P450 enzyme, a Putidaredoxin complexed with cofactors 2Fe-2S, a NADH-dependent Putidaredoxin reductase.