Chymase
Chymases are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes. They show broad peptidolytic activity and are involved in a variety of functions. For example, chymases are released by mucosal mast cells upon challenge with parasites and parasite antigens promoting an inflammatory response, and chymase mcp1 and mcp2 are used for marker for mast cell degranulation in parasite infection such as Nematode, Trichuris muris Chymases are also known to convert angiotensin I to angiotensin II and thus play a role in hypertension and atherosclerosis.
Because of its role in inflammation it has been investigated as a target in the treatment of asthma.
