Chronic allograft nephropathy


Chronic allograft nephropathy is a kidney disorder which is the leading cause of kidney transplant failure, occurring months to years after the transplant.

Symptoms

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.

Diagnosis

CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.

Pathology

The histopathology is characterized by interstitial fibrosis, tubular atrophy,
fibrotic intimal thickening of arteries and glomerulosclerosis.