Dr. Chris Nwabueze Ngige joined politics, becoming a member of the People's Democratic Party. In 1999, he was Assistant National Secretary and Zonal Secretary of the Peoples Democratic Party in the South East region of Nigeria. In 2003, he was elected governor of Anambra State in controversial circumstances. He quickly broke ranks with his political godfather, Chris Uba brother of Andy Uba, after an unsuccessful attempt on 10 July 2003 to have him removed from office, through a fabricated letter of resignation which the state assembly accepted. In August, 2005, an election Tribunal led by Justice Nabaruma nullified Ngige's 2003 victory. He appealed to the Nigerian Federal Court of Appeal, but the annulment was confirmed on 15 March 2006, in a judgment awarding victory to Peter Obi of the All Progressives Grand Alliance. No further appeals were possible, and Ngige accepted the judgment in good faith, calling on the people of Anambra to give their support to his successor. Following Peter Obi's subsequent impeachment, Ngige attempted to participate in state governorship elections in April 2007, but was frustrated by the Independent National Electoral Commission and federal 'disqualification', even after a Federal High Court had voided the disqualification. In the final event, Obi's impeachment was overturned anyway, and Obi served out his four years. At the time, Ngige was also severely criticized for appearing naked at the dreaded Okija voodoo shrine during his campaign to be made governor. On 6 February 2010, Ngige again contested for the governorship of Anambra State. Other notable politicians who contested with him included Andy Uba, Charles Soludo, Nicholas Ukachukwu, Mrs. Uche Ekwunife, Ralph Nwosu, and the incumbent governor, Peter Obi. In all, there were 25 candidates for that election. Peter Obi won that election and started his second term as the governor of Anambra State. In April 2011, Ngige ran for election for Senator of Anambra Central, on the Action Congress of Nigeria platform. After voting problems in some areas of the constituency on 9 April, the election in these areas was held on 25 April and Ngige was declared the winner over former Minister of Information and Communications Professor Dora Akunyili of the APGA, with 69,765 votes to Akunyili's 69,292. Ngige's tenure as a Senator of the Federal Republic of Nigeria came to an end following his defeat in the 2015 election by Hon. Mrs Uche Ekwunife who has been sworn in as the Senator representing Anambra Central Senatorial District in the current 8th National Assembly of Nigeria. On 11 November 2015, Ngige was named minister of Labour and Employment by President Muhammadu Buhari. In 2019, Chris Ngige was Nominated by President Muhammadu Buhari as a returning minister for screening by the house of assembly. On the 21st of August 2019, he was sworn in by the president as the Minister of Labour and Employment
