Comparative genomic analysis has led to the identification of 2 conserved signature indels which are uniquely found in members of the phylum Chlorobi and are thus characteristic of the phylum. The first indel is a 28-amino-acid insertion in DNA polymerase III and the second is a 12 to 14 amino acid insertion in alanyl-tRNA synthetase. These indels are not found in any other bacteria and thus serve as molecular markers for the phylum. In addition to the conserved signature indels, 51 proteins which are uniquely found in members of the phylum Chlorobi. 65 other proteins have been identified which are unique to the Chlorobi phylum, however these proteins are missing in several Chlorobi species and are not distributed throughout the phylum with any clear pattern. This means that significant gene loss may have occurred, or the presence of these proteins may be a result of horizontal gene transfer. Of these 65 proteins, 8 are found only in Chlorobium luteolum and Chlorobium phaeovibrioides. These two species form a strongly supported clade in phylogenetic trees and a close relationship between these species is further supported by the unique sharing of these 8 proteins.
Relatedness of ''Chlorobi'' to ''Bacteroidetes'' and ''Fibrobacteres'' phyla
Species from the Bacteroidetes and Chlorobi phyla branch very closely together in phylogenetic trees, indicating a close relationship. Through the use of comparative genomic analysis, 3 proteins have been identified which are uniquely shared by virtually all members of the Bacteroidetes and Chlorobi phyla. The sharing of these 3 proteins is significant because other than these 3 proteins, no proteins from either the Bacteroidetes or Chlorobi phyla are shared by any other groups of bacteria. Several conserved signature indels have also been identified which are uniquely shared by members of the Bacteroidetes and Chlorobi phyla. The presence of these molecular signatures supports the close relationship of the Bacteroidetes and Chlorobi phyla. Additionally, the phylum Fibrobacteres is indicated to be specifically related to these two phyla. A clade consisting of these three phyla is strongly supported by phylogenetic analyses based upon a number of different proteins These phyla also branch in the same position based upon conserved signature indels in a number of important proteins. Lastly and most importantly, two conserved signature indels and one signature protein PG00081 have been identified that are uniquely shared by all of the species from these three phyla. All of these results provide compelling evidence that the species from these three phyla shared a common ancestor exclusive of all other bacteria and it has been proposed that they should all recognized as part of a single “FCB”superphylum.