In the 2005-06 season, Samb played for WTC Cornellá in the Spanish second division, averaging 9.6 points, 7.7 rebounds and 3.1 blocks, shooting 51.4% from the field and 76.1% from the free-throw line, playing an average of 26 minutes per game in 29 games. He led the league in blocked shots, registering more blocks than the totals of all but one team in the league. Samb was drafted by the Los Angeles Lakers in the second round of the 2006 NBA Draft, but was traded that day to the Detroit Pistons for shooting guardMaurice Evans. After being drafted, he played for the Pistons in the NBA Summer League, averaging 7.2 points, 4.8 rebounds and 1.8 blocks, while shooting 65.2% from the field and 60.0% from the free-throw line. He would be loaned back to the same Spanish outfit for 2006–07. In his second season with Cornellá, Samb averaged 10.5 points, 7.3 rebounds and 2.9 blocks, while shooting 52% from the field, and 61% from the free-throw line, playing 24 minutes per game in only 19 games, in an injury-plagued season. Joining the Pistons for another Summer League, Samb posted slightly better numbers than in the previous edition, starting in four and playing in all five games. Subsequently, he signed a contract with the Pistons on July 17, 2007. On November 16, 2007, Samb played his first NBA regular season game: against the Los Angeles Lakers, he had four rebounds, two points and two blocks in 15 minutes, before being allocated to the NBA Development League, with the Fort Wayne Mad Ants. On December 14, in his second D-League game, against the Dakota Wizards, Samb took an elbow to his mouth and lost two front teeth. The teeth, knocked out at the root, were subsequently put in a saline solution and he was taken to a dentist to have them reset. He also suffered a probable upper jawbone fracture. Samb was recalled to the NBA on December 21, switching to the Mad Ants again on January 29, 2008. On February 3, he recorded a triple double with the Ants, with 12 points, 12 rebounds and 11 blocks. On March 22, he was once again recalled to the Pistons. On November 3, 2008, Samb was traded along with Antonio McDyess and Chauncey Billups to the Denver Nuggets, in exchange for Allen Iverson. He was later assigned to the Colorado 14ers, a team associated with the Nuggets in the NBA Development League. On January 5, 2009, the Nuggets traded Samb, along with cash considerations, to the Los Angeles Clippers for a conditional second-round draft pick. On February 16, 2009, Samb was waived by the Clippers. On March 2, he signed a 10-day contract with the New York Knicks. After this expired on March 12, 2009, the Knicks signed him to a second 10-day contract and, on March 23, released the player, who made appeared in 2 games with them. On October 1, 2009 he signed a one-month contract with Spanish giants Real Madrid. He only appeared in one game and was released in November. He was on the Toronto Raptors' roster for the 2010 NBA Summer League. In the final game of Summer League, Samb scored 11 points, grabbed 15 rebounds and 7 blocked shots. On November 1, 2010, Samb was drafted by the Sioux Falls Skyforce with the 11th overall pick in the 2010 NBA Development League Draft. He did not make the final 10 man roster, however. Samb signed with defending Iranian Super League champions Mahram Tehran in December 2010.
