He wanted to marry Archduchess Maria Amalia of Austria, the eighth child of Empress Maria Theresa. He was well known in the Austrian court, and Maria Amalia was also in love with him. However, Maria Theresa deemed him of insufficient rank to marry an archduchess. Moreover, she wanted to strengthen Austria's alliance with the House of Bourbon by marrying a daughter to Ferdinand, Duke of Parma, a grandson of the French king, Louis XV. This was to be Maria Amalia, due to the death of another daughter, Maria Josepha. Maria Amalia's older brother, Emperor Joseph II, also favored the marriage of his sister to the Duke of Parma, who was the younger brother of his beloved wife, Isabella. So in 1769, Maria Amalia was married to Ferdinand against her will. This decision not only permanently embittered Charles against the Empress and Austria but also Maria Amalia against her mother.
Bavarian claims
His cousin Maximilian III Joseph, Elector of Bavaria, died without children in December 1777. Their mutual cousin, Charles Theodore of Sulzbach, then Elector Palatine, succeeded Maximilian Joseph as prince elector. However, Charles Theodore had no legitimate children to inherit his combined holdings in Bavaria and the Palatinate, so Charles August became the heir to the Wittelsbach territories of: Zweibrucken, the duchies of Neuburg, Sulzbach, Julich and Berg, in addition to the electorates of the Palatinate and Bavaria. Charles Theodore preferred the Palatinate and therefore tried to exchange parts of his Bavarian inheritance with Joseph II of Austria in return for parts of the Austrian Netherlands. Although Charles Theodore would have preferred to exchange the entire complex of territories of Bavaria for the Austrian Netherlands, the Austrian court would not countenance an outright exchange and a final arrangement was never concluded. Charles August, being next in line for the Bavarian territories, objected strenuously. He obtained the active support of Frederick the Great of Prussia and the Elector Frederick Augustus III of Saxony. The French government under Foreign Minister Vergennes passively supported Charles II August despite France's formal alliance with Austria. The War of the Bavarian Succession was resolved without prolonged fighting; Charles Theodore succeeded in all of Bavaria except for the district east of the Inn River, known as the Innviertel, assigned to Austria by the Peace of Teschen. A second attempt to make the exchange in 1784 was also opposed by Charles August, again with Prussian support, and also failed. However, Charles Theodore outlived Charles August who, dying in 1795 without sons, left his claim to Bavaria to his brother, Maximilian Joseph, who would succeed in vastly enlarging that realm and, in 1806, becoming its king.
Marriage
In Dresden in 1774, Charles married Maria Amalia of Saxony, daughter of Frederick Christian, Elector of Saxony. Their only child, Charles Augustus Frederick, died at the age of eight on 21 August 1784. Upon the death of Charles II August the title of Duke of Zweibrücken was inherited by his brother Maximilian, the first of many to which he would succeed. Charles August was the principal owner of the famous Karlsberg Castle. He died at Mannheim in 1795.