Cascade Township was formed from parts of Hepburn and Plunketts Creek townships on August 9, 1843. It is named for the series of waterfalls or cascades that are abundant in the many mountain streams of Cascade Township. Many of the early settlers in Cascade Township were Irish Catholics. Under the leadership of Michael Kelly they established the village of Kellyburg in one of the most remote parts of Lycoming County. Michael Kelly also cut a road deep into Cascade Township from a sawmill along Lycoming Creek, and he built a gristmill and a sawmill in the township. Kelly left the area in 1877 following a bitter defeat in the sheriffelection of 1872, moving to Kansas and residing there until his 1883 death. Michael Kelly also helped his fellow Catholics establish the mission parish of St. Mary's.
As of the census of 2000, there were 419 people, 172 households, and 130 families residing in the township. The population density was 10.2 people per square mile. There were 245 housing units at an average density of 6.0/sq mi. The racial makeup of the township was 98.81% White, 0.72% Native American and 0.48% Asian. Hispanic or Latino of any race were 0.72% of the population. There were 172 households, out of which 25.0% had children under the age of 18 living with them, 66.3% were married couplesliving together, 6.4% had a female householder with no husband present, and 24.4% were non-families. 18.6% of all households were made up of individuals, and 7.0% had someone living alone who was 65 years of age or older. The average household size was 2.44 and the average family size was 2.78. In the township the population was spread out, with 21.5% under the age of 18, 4.5% from 18 to 24, 29.4% from 25 to 44, 26.3% from 45 to 64, and 18.4% who were 65 years of age or older. The median age was 43 years. For every 100 females, there were 106.4 males. For every 100 females age 18 and over, there were 101.8 males. The median income for a household in the township was $39,896, and the median income for a family was $45,208. Males had a median income of $31,000 versus $22,813 for females. The per capita income for the township was $19,465. About 5.1% of families and 8.6% of the population were below the poverty line, including 4.5% of those under age 18 and 15.5% of those age 65 or over.