COVID-19 vaccine
A COVID‑19 vaccine is a biotechnology intended to provide acquired immunity against coronavirus disease 2019. In July 2020, 218 vaccine candidates were in development, although no candidate has completed clinical trials to prove its safety and efficacy. In July, 24 vaccine candidates were announced or undergoing clinical trials, with two beginning Phase III and seven in Phase I-II.
Previous attempts to develop a vaccine against the coronavirus diseases SARS and MERS established considerable knowledge about the structure and function of coronaviruseswhich accelerated rapid development during early 2020 of varied technology platforms for a COVID‑19 vaccinebut all the previous coronavirus vaccine candidates failed in early-stage clinical trials, with none being advanced to licensing.
The Coalition for Epidemic Preparedness Innovations which is organizing a billion worldwide fund for rapid investment and development of vaccine candidatesindicated in April that a vaccine may be available under emergency use protocols in less than 12 months or by early 2021. On 4May 2020, the WHO organized a telethon which received.1billion in pledges from forty countries to support rapid development of vaccines to prevent COVID‑19 infections. At the same time, the WHO also announced deployment of an international "Solidarity trial" for simultaneous evaluation of several vaccine candidates reaching Phase II-III clinical trials.
History
In February 2020, the World Health Organization said it did not expect a vaccine against severe acute respiratory syndrome coronavirus 2, the causative virus, to become available in less than 18 months.Vaccines have been produced against several animal diseases caused by coronaviruses, including infectious bronchitis virus in birds, canine coronavirus, and feline coronavirus.
Previous projects to develop vaccines for viruses in the family Coronaviridae that affect humans have been aimed at severe acute respiratory syndrome and Middle East respiratory syndrome. Vaccines against SARS and MERS have been tested in non-human animal models.
For SARS, as of 2020 there is no cure or protective vaccine that has been shown to be both safe and effective in humans. According to research papers published in 2005 and 2006, the identification and development of novel vaccines and medicines to treat SARS was a priority for governments and public health agencies around the world at that time.
There is also no proven vaccine against MERS. When MERS became prevalent, it was believed that existing SARS research may provide a useful template for developing vaccines and therapeutics against a MERS-CoV infection. As of March 2020, there was one MERS vaccine which completed PhaseI clinical trials in humans, and three others in progress, all of which are viral-vectored vaccines: two adenoviral-vectored, and one MVA-vectored.
Globally accelerated development
After a novel coronavirus pneumonia was detected in December 2019, the genetic sequence of COVID‑19 was published on 11 January 2020, triggering an urgent international response to prepare for the outbreak and hasten development of a preventative vaccine. The rapidly growing infection rate of COVID‑19 worldwide during early 2020 stimulated international alliances and government efforts to urgently organize resources to make multiple vaccines on shortened timelines, with four vaccine candidates entering human evaluation in March.A vaccine for an infectious disease has never before been produced in less than several years, and no vaccine exists for preventing a coronavirus infection. As of April, CEPI estimates that as many as six of the 115 vaccine candidates against COVID‑19 should be chosen by international coalitions for development through PhaseII–III trials, and three should be streamlined through regulatory and quality assurance for eventual licensing at a total cost of at least billion. Another analysis estimates 10 candidates will need simultaneous initial development, before a select few are chosen for the final path to licensing.
The vaccine effort is being prioritized for speed of rigorous clinical evaluation for safety and efficacy, financing, and planning to manufacture billions of doses, and eventual worldwide deployment and equitable access among developed and undeveloped countries. WHO, CEPI, and the Gates Foundation are committing money and organizational resources for the prospect that several vaccines will be needed to prevent continuing COVID‑19 infection. The vaccines will require custom formulation, special packaging, transportation, and storage in all 200 countries with infected citizens. The WHO estimates a total cost of billion to develop a suite of three or more vaccines having different technologies and distribution to prevent COVID‑19 infections worldwide.
International organizations
Organizations have formed international alliances to expedite vaccine development and prepare for distribution, including the WHO which is facilitating collaboration, accelerated research, and international communications on a scale unprecedented in history, beginning in early May by raising.1billion in pledges. The WHO also implemented an Access to COVID‑19 Tools Accelerator for coordinating global vaccine development. In July, the WHO announced that 165 countries, representing up to 60% of the world population, had agreed to a WHO COVAX plan for fair and equitable distribution of an eventual licensed vaccine, assuring that each participating country would receive a guaranteed share of doses to vaccinate the most vulnerable 20% of its population by the end of 2021.The Coalition for Epidemic Preparedness Innovations is working with international health authorities and vaccine developers to create another billion fund in a global partnership between public, private, philanthropic, and civil society organizations for accelerated research and clinical testing of eight vaccine candidates, with the 2020-21 goal of supporting three candidates for full development to licensing. The United Kingdom, Canada, Belgium, Norway, Switzerland, Germany and the Netherlands had already donated million to CEPI by early May. The Bill & Melinda Gates Foundation, a private charitable organization dedicated to vaccine research and distribution, is donating million in support of CEPI for research and public educational support on COVID‑19 vaccines. The Global Research Collaboration for Infectious Disease Preparedness is working closely with the WHO and member states to identify specific funding of research priorities needed for a COVID‑19 vaccine, coordinating among the international funding and research organizations to maintain updated information on vaccine progress and avoid duplicate funding.
The International Severe Acute Respiratory and Emerging Infection Consortium is organizing and disseminating clinical information on COVID‑19 research to inform public health policy on eventual vaccine distribution.
On 4 June, a virtual summit was coordinated from London, UK among private and government representatives of 52 countries, including 35 heads of state from G7 and G20 nations, to raise billion in support of the Global Alliance for Vaccines and Immunisation to prepare for COVID‑19 vaccinations of 300million children in under-developed countries through 2025. Major contributions were $1.6billion from The Gates Foundation and million per year over five years by the UK government.
National governments
National governments dedicating resources for national or international investments in vaccine research, development, and manufacturing beginning in 2020 included the Canadian government which announced million in funding for 96 research vaccine research projects at Canadian companies and universities, with plans to establish a "vaccine bank" of several new vaccines that could be used if another coronavirus outbreak occurs. A further investment of billion was added to support clinical trials in Canada and develop manufacturing and supply chains for vaccines. On 4May, the Canadian government committed million to the WHO's live streaming effort to raise billion for COVID‑19 vaccines and preparedness. In China, the government is providing low-rate loans to vaccine developers through its central bank, and has enabled land transfers to build production plants. As of June 2020, six of the eleven COVID‑19 vaccine candidates in early-stage human testing were developed by Chinese organizations. Three Chinese vaccine companies and research institutes are supported by the government for financing research, conducting clinical trials, and manufacturing the most promising vaccine candidates, while prioritizing rapid evidence of efficacy over safety. On 18 May, China had pledged billion to support overall efforts by the WHO for programs against COVID‑19.Among European Union countries, France announced a million investment in a COVID‑19 vaccine research consortium via CEPI involving the Institut Pasteur, Themis Bioscience, and the University of Pittsburgh, bringing CEPI's total investment in COVID‑19 vaccine development to million by May. In March, the European Commission made an million investment in CureVac, a German biotechnology company, to develop a mRNA vaccine. The German government announced a separate million investment in CureVac in June. Belgium, Norway, Switzerland, Germany, and the Netherlands have been major contributors to the CEPI effort for COVID‑19 vaccine research in Europe.
In April, the UK government formed a COVID‑19 vaccine taskforce to stimulate British efforts for rapidly developing a vaccine through collaborations of industry, universities, and government agencies across the vaccine development pipeline, including clinical trial placement at UK hospitals, regulations for approval, and eventual manufacturing. The vaccine development initiatives at the University of Oxford and Imperial College of London were financed with million in April.
diagram comparing a traditional vaccine development timeline to a possible expedited timeline
The United States Biomedical Advanced Research and Development Authority, a federal agency that funds disease-fighting technology, announced investments of nearly billion to support American COVID‑19 vaccine development, and preparation for manufacturing the most promising candidates. On 16 April, BARDA made a million investment in the vaccine developer, Moderna and its partner, Johnson & Johnson. BARDA has an additional billion to spend on vaccine development, and will have roles in other American investment for development of six to eight vaccine candidates to be in clinical studies over 2020-21 by companies such as Sanofi Pasteur and Regeneron. On 15 May, the US government announced federal funding for a fast-track program called Operation Warp Speed, which has the goals of placing diverse vaccine candidates in clinical trials by the fall of 2020, and manufacturing 300million doses of a licensed vaccine by January 2021. The project chief advisor is Moncef Slaoui and its Chief Operating Officer is Army General Gustave Perna. In June, the Warp Speed team said it would work with seven companies developing COVID‑19 vaccine candidates: Moderna, Johnson & Johnson, Merck, Pfizer, and the University of Oxford in collaboration with AstraZeneca, as well as two others.
Partnerships and competition
WHO Solidarity trial
The WHO has developed a multinational coalition of vaccine scientists defining a Global Target Product Profile assess the development of the most promising candidate vaccines; 2) map candidate vaccines and their clinical trial worldwide, publishing a frequently-updated "landscape" of vaccines in development; 3) rapidly evaluate and screen for the most promising candidate vaccines simultaneously before they are tested in humans; and 4) design and coordinate a multiple-site, international randomized controlled trialthe Solidarity trial for vaccinesto enable simultaneous evaluation of the benefits and risks of different vaccine candidates under clinical trials in countries where there are high rates of COVID‑19 disease, ensuring fast interpretation and sharing of results around the world. The WHO vaccine coalition will prioritize which vaccines should go into PhaseII and III clinical trials, and determine harmonized PhaseIII protocols for all vaccines achieving the pivotal trial stage.Adaptive design for the Solidarity trial
A clinical trial design in progress may be modified as an "adaptive design" if accumulating data in the trial provide early insights about positive or negative efficacy of the treatment. The WHO Solidarity trial of multiple vaccines in clinical studies during 2020 will apply adaptive design to rapidly alter trial parameters across all study sites as results emerge. Candidate vaccines may be added to the Solidarity trial as they become available if priority criteria are met, while vaccine candidates showing poor evidence of safety or efficacy compared to placebo or other vaccines will be dropped from the international trial.Adaptive designs within ongoing PhaseII-III clinical trials on candidate vaccines may shorten trial durations and use fewer subjects, possibly expediting decisions for early termination or success, avoiding duplication of research efforts, and enhancing coordination of design changes for the Solidarity trial across its international locations.
Partnerships, competition, and distribution
Large pharmaceutical companies with experience in making vaccines at scale, including Johnson & Johnson, AstraZeneca, and GlaxoSmithKline, are forming alliances with biotechnology companies, national governments, and universities to accelerate progression to an effective vaccine. To combine financial and manufacturing capabilities for a pandemic adjuvant technology, GSK joined with Sanofi in an uncommon partnership of multinational companies to support accelerated vaccine development.During a pandemic on the rapid timeline and scale of COVID‑19 infections during 2020, international organizations like the WHO and CEPI, vaccine developers, governments and industry are evaluating distribution of the eventual vaccine. Individual countries producing a vaccine may be persuaded to favor the highest bidder for manufacturing or provide first-service to their own country. Experts emphasize that licensed vaccines should be available and affordable for people at the frontline of healthcare and having the greatest need. Under their agreement with AstraZeneca, the University of Oxford vaccine development team and UK government agreed that UK citizens would not get preferential access to a new COVID‑19 vaccine developed by the taxpayer-funded university, but rather consented to having a licensed vaccine distributed multinationally in cooperation with the WHO. Several companies plan to initially manufacture a vaccine at low cost, then increase costs for profitability later if annual vaccinations are needed and as countries build stock for future needs.
The WHO and CEPI are developing financial resources and guidelines for global deployment of three or more safe, effective COVID‑19 vaccines, recognizing the need is different across countries and population segments. For example, successful COVID‑19 vaccines would likely be allocated first to healthcare personnel and populations at greatest risk of severe illness and death from COVID‑19 infection, such as the elderly or densely-populated impoverished people. Both the WHO and CEPI have discussed concerns that affluent countries should not have priority access to the global supply of eventual COVID‑19 vaccines.
Allegations of Russian espionage
The UK's National Cyber Security Centre, together with the Canadian Communications Security Establishment, the United States Department for Homeland Security Cybersecurity Infrastructure Security Agency, and the US National Security Agency have jointly alleged that Russian state-backed hackers have been trying to steal COVID-19 treatment and vaccine research from academic and pharmaceutical institutions in other countries; Russia has denied these allegations.Compressed timelines
issues, safety concerns for vulnerable populations, and manufacturing challenges for producing billions of doses are compressing schedules to shorten the standard vaccine development timeline, in some cases combining clinical trial steps over months, a process typically conducted sequentially over years. As an example, Chinese vaccine developers and the government Chinese Center for Disease Control and Prevention began their efforts in January 2020, and by March were pursuing numerous candidates on short timelines, with the goal to showcase Chinese technology strengths over those of the United States, and to reassure the Chinese people about the quality of vaccines produced in China.In the haste to provide a vaccine on a rapid timeline for the COVID‑19 pandemic, developers and governments are accepting a high risk of "short-circuiting" the vaccine development process, with one industry executive saying: "The crisis in the world is so big that each of us will have to take maximum risk now to put this disease to a stop". Multiple steps along the entire development path are evaluated, including the level of acceptable toxicity of the vaccine, targeting vulnerable populations, the need for vaccine efficacy breakthroughs, the duration of vaccination protection, special delivery systems, dose regimen, stability and storage characteristics, emergency use authorization before formal licensing, optimal manufacturing for scaling to billions of doses, and dissemination of the licensed vaccine. If a vaccine fails in development, not providing adequate prevention against the virusdata show that 84-90% of vaccine candidates fail in PhaseIII clinical trialsthe investment by a manufacturer in a vaccine candidate may exceed billion and end with millions of useless doses. In the case of COVID‑19 specifically, a vaccine efficacy of 70% may be enough to stop the pandemic, but if it has only 60% efficacy, outbreaks may continue; an efficacy of less than 60% will not provide enough herd immunity to stop the spread of the virus alone.
As the pandemic expands during 2020, research at universities is obstructed by physical distancing and closing of laboratories. Globally, supplies critical to vaccine research and development are increasingly scarce due to international competition or national sequestration. Timelines for conducting clinical researchnormally a sequential process requiring yearsare being compressed into safety, efficacy, and dosing trials running simultaneously over months, potentially compromising safety assurance.
Technology platforms
In April, CEPI scientists reported that ten different technology platforms were under research and development during early 2020 to create an effective vaccine against COVID‑19. According to CEPI, the platforms based on DNA or messenger RNA, i.e. DNA vaccines or RNA vaccines, offer considerable promise to alter COVID‑19 antigen functions for strong immune responses, and can be rapidly assessed, refined for long-term stability, and prepared for large-scale production capacity. Other platforms being developed in 2020 focus on non-replicating viral vectors, peptides, recombinant proteins, live attenuated viruses, and inactivated viruses.In general, the vaccine technologies being developed for COVID‑19 are not like vaccines already in use to prevent influenza, but rather are using "next-generation" strategies for precision on the COVID‑19 infection mechanisms, while hastening development for eventually preventing infection with a new vaccine. Vaccine platforms in development are also designed to address mechanisms for infection susceptibility to COVID‑19 in specific population subgroups, such as the elderly, children, pregnant women, and people with existing weakened immune systems.
| Molecular platform | Total number of candidates | Number of candidates in human trials |
| Non-replicating viral vector | 27 | 5 |
| RNA-based | 27 | 5 |
| Protein subunit | 66 | 5 |
| DNA-based | 15 | 4 |
| Inactivated virus | 13 | 4 |
| Virus-like particle | 10 | 1 |
| Undefined | 42 | 0 |
| Replicating viral vector | 18 | 0 |
| Live attenuated virus | 4 | 0 |
| Replicating bacterial vector | 1 | 0 |
| Combined | 218 | 24 |
Vaccine candidates
CEPI classifies development stages for vaccines as either "exploratory", "preclinical", or initiation of PhaseI safety studies in healthy people.Some 205 total vaccine candidates are in early stages of development as either confirmed active projects or in "exploratory" or "preclinical" development, as of mid-July.
PhaseI trials test primarily for safety and preliminary dosing in a few dozen healthy subjects, while PhaseII trialsfollowing success in PhaseIevaluate immunogenicity, dose levels and adverse effects of the candidate vaccine, typically in hundreds of people. A PhaseI–II trial consists of preliminary safety and immunogenicity testing, is typically randomized, placebo-controlled, and at multiple sites, while determining more precise, effective doses. PhaseIII trials typically involve more participants, including a control group, and test effectiveness of the vaccine to prevent the disease, while monitoring for adverse effects at the optimal dose.
Clinical trials started in 2020
| Vaccine candidates Developers, sponsors | Technology | Current phase Design | Completed phase Immune response, adverse effects | Locations | Duration |
| AZD1222 University of Oxford, AstraZeneca | Modified chimp adenovirus vector | UK | May 2020Aug 2021 | ||
| mRNA-1273 Moderna, NIAID, BARDA | Lipid nanoparticle dispersion containing messenger RNA | US | Jul 2020Oct 2022 | ||
| Ad5-nCoV CanSinoBIO, Beijing Institute of Biotechnology of the Academy of Military Medical Sciences | Recombinant adenovirus type 5 vector | China | MarDec 2020 | ||
| BNT162 a1, b1, b2, c2 BioNTech, Fosun Pharma, Pfizer | RNA | Germany, US | Apr 2020May 2021 | ||
| CoronaVac Sinovac | Inactivated SARS-CoV-2 virus | China | AprDecember 2020 in Xuzhou MayJuly 2020 in Renqiu | ||
| INO-4800 Inovio, CEPI, Korea National Institute of Health, International Vaccine Institute | DNA plasmid delivered by electroporation | US, South Korea | AprNov 2020 | ||
| Unnamed Peking Union Medical College | Inactivated SARS-CoV-2 virus | China | Jun 2020Sep 2021 | ||
| AG0301-COVID19 AnGes Inc., AMED | DNA plasmid | Japan | Jun 2020Jul 2021 | ||
| COVID‑19/aAPC Shenzhen Genoimmune Medical Institute | Lentiviral vector, pathogen-specific artificial antigen presenting dendritic cells | China | Mar 20202023 | ||
| LV-SMENP-DC Shenzhen Genoimmune Medical Institute | Lentiviral minigene vaccine, dendritic cells modified with lentiviral vector | China | Mar 20202023 | ||
| Unnamed Sinopharm: Beijing Institute of Biological Products, Wuhan Institute of Biological Products | Inactivated COVID‑19 virus | China | Apr 2020Nov 2021 | ||
| LNP-nCoVsaRNA MRC clinical trials unit at Imperial College London | Messenger RNA | UK | Jun 2020Jul 2021 | ||
| NVX-CoV2373 Novavax | SARS-CoV-2 recombinant spike protein nanoparticle with adjuvant | Australia | May 2020Jul 2021 | ||
| Gam-COVID-Vac Lyo Gamaleya Research Institute | Non-replicating viral vector | Russia | Jun 2020Aug 2020 | ||
| GX-19 Genexine consortium, International Vaccine Institute | DNA | South Korea | Jun 2020Jun 2022 | ||
| SCB-2019 Clover Biopharmaceuticals, GSK | Spike protein trimeric subunit with GSK adjuvant | Australia | Jun 2020Mar 2021 | ||
| COVAX-19 Vaxine Pty Ltd | Recombinant protein | Australia | Jun 2020Jul 2021 | ||
| CVnCoV CureVac, CEPI | Messenger RNA | Belgium, Germany | Jun 2020Aug 2021 | ||
| Unnamed PLA Academy of Military Science, Walvax Biotech | Messenger RNA | China | Jun 2020Dec 2021 | ||
| Unnamed Anhui Zhifei Longcom Biopharmaceutical Co. Ltd. | Recombinant protein subunit | China | Jun 2020Sep 2021 | ||
| Unnamed Medicago | Plant-derived virus-like particle, recombinant, using GSK adjuvant | Canada | Jul 2020Apr 2021 |
| Vaccine candidates Developers, sponsors | Technology | Start date announced |
| DPX-COVID‑19 IMV, Inc., Canadian Immunization Research Network | Protein subunit, lipid-based delivery | Mid 2020 |
| PittCoVacc University of Pittsburgh | Protein subunit, microneedle arrays | Mid 2020 |
| Unnamed University of Cambridge | Protein subunit, S protein | Mid 2020 |
| LUNAR-COV19 Arcturus Therapeutics, Duke University-NUS | RNA, mRNA | Mid 2020 |
| Unnamed Sanofi Pasteur, GSK | Protein subunit, S protein | Mid 2020 |
| Unnamed Cobra Biologics, Karolinska Institute | DNA plasmid | Mid 2020 |
| Unnamed Generex Biotech | Synthetic viral peptides combined with Ii-key immune activation | Mid 2020 |
| Ad26 Janssen Pharmaceutica, BIDMC | Non-replicating viral vector | Late Jul 2020 |
| Unnamed SK Bioscience, Government of Saskatchewan, KCDC | COVID-19 antigen subunits | Sep 2020 |
| CoroFlu UW-Madison, FluGen, Bharat Biotech | Self-limiting influenza virus | Late 2020 |
| Unnamed Takis, Applied DNA Sciences, Evvivax | DNA | Late 2020 |
| AdCOVID Altimmune, University of Alabama at Birmingham | Non-replicating viral vector, intranasal | Late 2020 |
| Unnamed Vaxart, Emergent BioSolutions | Non-replicating viral vector, oral | JunSep 2020 |
| Unnamed VBI Vaccines, NRC Canada | Pan-coronavirus | After Nov 2020 |
Preclinical research
In April 2020, the WHO issued a statement representing dozens of vaccine scientists around the world, pledging collaboration to speed development of a vaccine against COVID‑19. The WHO coalition is encouraging international cooperation between organizations developing vaccine candidates, national regulatory and policy agencies, financial contributors, public health associations, and governments, for eventual manufacturing of a successful vaccine in quantities sufficient to supply all affected regions, particularly low-resource countries.Industry analysis of past vaccine development shows failure rates of 84-90%. Because COVID‑19 is a novel virus target with properties still being discovered and requiring innovative vaccine technologies and development strategies, the risks associated with developing a successful vaccine across all steps of preclinical and clinical research are high.
To assess potential for vaccine efficacy, unprecedented computer simulations and new COVID‑19-specific animal models are being developed multinationally during 2020, but these methods remain untested by unknown characteristics of the COVID‑19 virus. Of the confirmed active vaccine candidates, about 70% are being developed by private companies, with the remaining projects under development by academic, government coalitions, and health organizations.
Most of the vaccine developers are small firms or university research teams with little experience in successful vaccine design and limited capacity for advanced clinical trial costs and manufacturing without partnership by multinational pharmaceutical companies. The general geographic distribution of COVID‑19 vaccine development involves organizations in the United States and Canada, together having about 46% of the world's active vaccine research, compared with 36% in Asian countries, including China, and 18% in Europe.
By July, one organization reported that 205 vaccine candidates were in development as either "exploratory/preclinical" projects or in PhaseI-III trials in human participants. The table in this section lists emerging vaccine candidates whose PhaseI trial starts are scheduled in 2020.
Scheduled Phase I trials in 2020
Many vaccine candidates under design or preclinical development for COVID‑19 will not gain approval for human studies in 2020 due to toxicity, ineffectiveness to induce immune responses or dosing failures in laboratory animals, or because of underfunding. The probability of success for an infectious disease vaccine candidate to pass preclinical barriers and reach PhaseI of human testing is 41-57%.Commitment to first-in-human testing of a vaccine candidate represents a substantial capital cost for vaccine developers, estimated to be from million to million for a typical PhaseI trial program, but possibly as much as million. For comparison, during the Ebola virus epidemic of 2013-16, there were 37 vaccine candidates in urgent development, but only one eventually succeeded as a licensed vaccine, involving a total cost to confirm efficacy in PhaseII–III trials of about billion.
Non-specific vaccines
Some vaccines have non-specific effects beyond the disease they prevent. Two existing vaccines are being tested to determine if either has a protective effect against COVID‑19.Assertions have been made that COVID‑19 mortality has been lower in countries having routine BCG vaccine administered against tuberculosis, though the World Health Organization has said there is no evidence that this vaccine is effective against the COVID‑19 virus.
In March 2020, a randomized trial of BCG vaccine to reduce COVID‑19 illness began in the Netherlands, seeking to recruit 1,000 healthcare workers. A further randomized trial in Australia is seeking to enroll 4,170 healthcare workers. A further 700 healthcare workers from Boston and Houston will be recruited in another trial, and 900 healthcare workers in Egypt are to participate in a trial registered by a university in Cairo, Egypt. An additional trial in the Netherlands is testing whether BCG vaccine provides protection for older people, recruiting 1,000 people over 65 years and 600 younger adults. A trial of BCG in 1,000 healthcare workers in Medellín, Colombia was registered on 24 April 2020. Other trials of BCG in healthcare workers were registered in late Aprilearly May: 1,100 participants in Brazil, 1,120 in France, 1,500 in Denmark, and 500 in South Africa. In May 2020, a trial seeking 900 people over 50 in Greece to test BCG vaccine as protection against COVID‑19 was registered.
A randomized placebo-controlled trial to test whether the measles-mumps-rubella vaccine can protect healthcare workers from COVID‑19 began with 200 participants during June 2020, in Cairo.
Potential limitations
The rapid development and urgency of producing a vaccine for the COVID‑19 pandemic may increase the risks and failure rate of delivering a safe, effective vaccine. One study found that between 2006 and 2015, the success rate of obtaining approval from PhaseI to successful PhaseIII trials was 16.2% for vaccines, and CEPI indicates a potential success rate of only 10% for vaccine candidates in 2020 development.An April 2020 CEPI report stated: "Strong international coordination and cooperation between vaccine developers, regulators, policymakers, funders, public health bodies and governments will be needed to ensure that promising late-stage vaccine candidates can be manufactured in sufficient quantities and equitably supplied to all affected areas, particularly low-resource regions." However, some 10% of the public perceives vaccines as unsafe and unnecessary, refusing vaccinationa global health threat called vaccine hesitancywhich increases the risk of further viral spread that could lead to COVID‑19 outbreaks.
Biosafety concern
Early research to assess vaccine efficacy using COVID‑19-specific animal models, such as ACE2-transgenic mice, other laboratory animals, and non-human primates, indicates a need for biosafety-level3 containment measures for handling live viruses, and international coordination to ensure standardized safety procedures.Antibody-dependent enhancement
Although the quality and quantity of antibody production by a potential vaccine is intended to neutralize the COVID‑19 infection, a vaccine may have an unintended opposite effect by causing antibody-dependent disease enhancement, which increases the virus attachment to its target cells and might trigger the cytokine storm when the person will be infected by the virus after vaccination. The vaccine technology platform, vaccine dose, timing of repeat vaccinations for the possible recurrence of COVID‑19 infection, and elderly age are factors determining the risk and extent of ADE. The antibody response to a vaccine is a variable of vaccine technologies in development, including whether the vaccine has precision in its mechanism, and choice of the route for how it is given.Causes of failure
Vaccine failures result from various factors. Inadequacies of the vaccine itself can occur from incomplete technology efficacy, ineffective vaccination route of administration, or failed cold chain distribution or storage. Host--related determinants that render a person susceptible to infection, such as genetics, health status, immune competence, age, and economic impact or cultural environment can be primary or secondary factors affecting the severity of infection and response to a vaccine. Elderly, allergen-hypersensitive, and obese people have susceptibility to compromised immunogenicity, which prevents or inhibits vaccine effectiveness, possibly requiring separate vaccine technologies for these specific populations or repetitive booster vaccinations to limit virus transmission.Vaccine developers have to invest resources internationally to find enough participants for PhaseII-III clinical trials when the virus has proved to be a "moving target" of changing transmission rate across and within countries, forcing companies to compete for trial participants. As an example in June, the Chinese vaccine developer, Sinovac, formed alliances in Malaysia, Canada, the UK, and Brazil among its plans to recruit trial participants and manufacture enough vaccine doses for a possible PhaseIII study in Brazil where COVID‑19 transmission was accelerating during June. As the COVID‑19 pandemic within China became more isolated and controlled, Chinese vaccine developers sought international relationships to conduct advanced human studies in several countries, creating competition for trial participants with other manufacturers and the international Solidarity trial organized by the WHO. In addition to competition over recruiting participants, clinical trial organizers may encounter people unwilling to be vaccinated due to vaccine hesitancy or disbelieving the science of the vaccine technology and its ability to prevent infection.
Having an insufficient number of skilled team members to administer vaccinations may hinder clinical trials that must overcome risks for trial failure, such as recruiting participants in rural or low-density geographic regions, and variations of age, race, ethnicity, or underlying medical conditions. Definition of vaccine safety, efficacy, and clinical endpoints in a PhaseIII trial may vary between the trials of different companies, such as defining the degree of side effects, infection or amount of transmission, and whether the vaccine prevents moderate or severe COVID‑19 infection. Further, there exists a possibility the virus will mutate with altered properties and different transmission or infection mechanisms than those the vaccine technology targets.
Cost
An effective vaccine for coronavirus could save trillions of dollars in global economic impact, according to one expert, and would therefore make any price tag in the billions look small in comparison. It is not yet known if it is even scientifically possible to create a vaccine for this virus, and it is not yet known exactly how much the vaccine development will cost. It is possible that billions of dollars could be invested without success.The European Commission organized and held a video conference of world leaders on 4 May 2020, at which billion was raised for coronavirus vaccine development.
After a vaccine is created, billions of doses will need to be manufactured and distributed worldwide. In April 2020, the Gates Foundation estimated that manufacturing and distribution could cost as much as billion.
Proposed challenge studies
Strategies are being considered for fast-tracking the licensing a vaccine against COVID‑19, especially by compressing the usually lengthy duration of PhaseII–III trials. Challenge studies have been implemented previously for diseases less deadly than COVID‑19 infection, such as common influenza, typhoid fever, cholera, and malaria. Following preliminary proof of safety and efficacy of a candidate vaccine in laboratory animals and healthy humans, controlled challenge studies might be implemented to bypass typical PhaseIII research, providing an accelerated path to license a COVID‑19 vaccine.A challenge study begins by simultaneously testing a vaccine candidate for immunogenicity and safety in laboratory animals and healthy adult volunteers, something normally a sequential process using animals first. If the initial tests are promising, the study proceeds by rapidly advancing the effective dose into a large-scale PhaseII–III trial in previously-uninfected, low-risk volunteers, who would then be deliberately infected with COVID‑19 for comparison with a placebo control group. Following the challenge, the volunteers would be monitored closely in clinics with life-saving resources, if needed. Volunteering for a vaccine challenge study during the COVID‑19 pandemic is likened to the emergency service of healthcare personnel for COVID‑19-infected people, firefighters, or organ donors.
Although challenge studies are ethically questionable due to the unknown hazards for the volunteers of possible COVID‑19 disease enhancement and whether the vaccine received has long-term safety, challenge studies may be the only option to rapidly produce an effective vaccine that will minimize the projected millions of deaths worldwide from COVID‑19 infection, according to some infectious disease experts. The World Health Organization has developed a guidance document with criteria for conducting COVID‑19 challenge studies in healthy people, including scientific and ethical evaluation, public consultation and coordination, selection and informed consent of the participants, and monitoring by independent experts.
Commercialization and equitable access
Commercialization issues
By June 2020, tens of billions of dollars were invested by corporations, governments, international health organizations, and university research groups to develop dozens of vaccine candidates and prepare for global vaccination programs to immunize against COVID‑19 infection. The corporate investment and need to generate value for public shareholders raised concerns about a "market-based approach" in vaccine development, costly pricing of eventual licensed vaccines, preferred access for distribution first to affluent countries, and sparse or no distribution to where the pandemic is most aggressive, as predicted for densely-populated, impoverished countries unable to afford vaccinations. The collaboration of the University of Oxford with AstraZeneca raised concerns about price and sharing of eventual profits from international vaccine sales, arising from whether the UK government and university as public partners had commercialization rights. AstraZeneca stated that initial pricing of its vaccine would not include a profit margin for the company while the pandemic was still expanding.In early June, AstraZeneca made deals with CEPI and GAVI to manufacture up to two billion vaccine doses if its Oxford vaccine candidate proves safe and effective. Commercialization of pandemic vaccines is a high-risk business venture, potentially losing billions of dollars in development and pre-market manufacturing costs if the candidate vaccines fail to be safe and effective. The multinational pharmaceutical company, Pfizer, indicated it was not interested in a government partnership, which would be a "third party" slowing progress in Pfizer's vaccine program. Further, there are concerns that rapid-development programs - like the Operation Warp Speed plan of the United States - are choosing vaccine candidates mainly for their manufacturing advantages to shorten the development timeline, rather than for the most promising vaccine technology having safety and efficacy.
Sovereignty
Favored distribution of vaccines within one or a few select countries, called "vaccine sovereignty", is a criticism of some of the vaccine development partnerships, such as for the AstraZeneca-University of Oxford vaccine candidate, concerning whether there may be prioritized distribution first within the UK and to the "highest bidder" - the United States, which made an advance payment of billion to secure 300million vaccine doses for Americans, even before the AstraZeneca-Oxford vaccine or a Sanofi vaccine is proved safe or effective. Concerns exist about whether some countries producing vaccines may impose protectionist controls by export or import restrictions that would stockpile a COVID‑19 vaccine for their own population.In June, the Serum Institute of India - a major manufacturer of global vaccines - received an advance order from AstraZeneca for 100million vaccine doses, and indicated that doses manufactured in India may go first to Indian citizens, as required by the Indian government. Similar preferential homeland distribution may exist if a vaccine is manufactured in Australia. Amid concerns that vaccines produced in China would be distributed there first, the Chinese government pledged in May that a successful Chinese vaccine would become a "global, public good," inferring enough doses would be manufactured for both national and global distribution.
Equitable access
As many of the efforts on vaccine candidates have open-ended outcomes, including a high potential for failure during human testing, CEPI, WHO, and charitable vaccine organizations, such as the Gates Foundation and GAVI, raised over billion during the first half of 2020 to fund vaccine development and preparedness for vaccinations, particularly for children in under-developed countries. CEPI had stated that governments should ensure implementation of a globally-fair allocation system for eventual vaccines, using a coordinated system of manufacturing capacity, financing and purchasing, and indemnification from liability to offset risks taken by vaccine developers. Having been created to monitor fair distribution of infectious disease vaccines to low- and middle-income countries, CEPI published guidelines in June for equitable distribution of COVID‑19 vaccines: 1) "prices for vaccines will be set as low as possible for territories that are or may be affected by an outbreak of a disease for which CEPI funding was used to develop a vaccine;" 2) "information, know-how and materials related to vaccine development must be shared with CEPI would have access to, and possible management of, intellectual property rights "CEPI would receive a share of financial benefits that might accrue from CEPI-sponsored vaccine development, to re-invest in support of its mission to provide global public health benefit"; and 5) data transparency among development partners should maintain the WHO Statement on Public Disclosure of Clinical Trial Results, and encourage publication of results in publicly-available journals. Some vaccine manufacturers opposed parts of these proposals.International groups, such as the Centre for Artistic Activism and Universities Allied for Essential Medicines, advocate for equitable access to licensed COVID‑19 vaccines. Scientists have encouraged that the WHO, CEPI, corporations, and governments collaborate to assure evidence-based allocation of eventual COVID‑19 vaccines determined on infection risk, particularly urgent vaccinations provided first for healthcare workers, vulnerable populations, and children.
A number of international scientists and catholic organisations have called for releasing clinical as well as experimental data for the manufacture of genetically engineered vaccines to the public domain. Similar to the development of the first polio vaccine that was never patented, an effective COVID-19 vaccine would be available for production and approval by a number of countries and pharmaceutical manufacturing centers worldwide, therefore allowing for a more even and cost-effective distribution on a global scale.
Liability
On 4 February 2020, US Secretary of Health and Human Services Alex Azar published a notice of declaration under the Public Readiness and Emergency Preparedness Act for medical countermeasures against COVID‑19, covering "any vaccine, used to treat, diagnose, cure, prevent, or mitigate COVID‑19, or the transmission of SARS-CoV-2 or a virus mutating therefrom", and stating that the declaration precludes "liability claims alleging negligence by a manufacturer in creating a vaccine, or negligence by a health care provider in prescribing the wrong dose, absent willful misconduct". The declaration is effective in the United States through 1October 2024.Misinformation
Social media posts have promoted a conspiracy theory that a COVID‑19 vaccine is already available. The patents cited by various social media posts have references to existing patents for genetic sequences and vaccines for other strains such as the SARS coronavirus, but not for COVID‑19.On 21 May 2020, the FDA made public the cease-and-desist notice it had sent to North Coast Biologics, a Seattle-based company that had been selling a purported "nCoV19 spike protein vaccine".