CORO1B

Function

• Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
• F-actin binding is essential for coronin 1B function in vivo.
• Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
• Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
• In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.
• Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.