The hotel, built in 1897, was designed for Arnold A. Rand by Boston architects Winslow & Wetherell, architects of many large hotels and office buildings. At the time of its construction, the Hotel Buckminster was one of the first hotels in Boston and the largest building in Kenmore Square.
In 1929, pioneer station WNAC Radio moved to new studios inside the Hotel Buckminster, with the entrance on the Brookline Avenue side, which would become the station's home for the next four decades. WNAC made history in January 1923 by linking up with New York's WEAF for the first chain broadcast, and later formed a new company known as the Yankee Network. A second station was added at the same location. A pioneer FM station was added in the late 1930s. Later, WNAC converted most of its studio space into one of Boston's first television studios and began broadcasting on Channel 7 in June, 1948. For the next twenty years, WNAC operated an AM, FM and television station in the hotel basement. During this time the station went through various facility upgrades and changes in ownership. One of its earliest and most successful radio announcers was Fred Lang, hired c. 1936, who read the news for Yankee network over WNAC through World War II: Lang also did Queen for a Day, the Tell-o-test Quiz Show, and a music show with a laid back flavor leading some to credit him with pioneering the "Easy Listening" style. However, with dwindling affiliates and an aging listening audience, the Yankee Network disbanded in 1967, with the flagship Boston station WNAC changing call letters to WRKO and becoming a Top 40 music station. The television station call letters WNAC-TV remained, and in 1968 the radio and TV operations moved to 7 Billfinch Place, near Government Center.
A portion of the building was used in the 1940s by a detachment of military police for the purpose of holding Italianprisoners of war during World War II.
A change in ownership in the 1960s led to the hotel being briefly renamed the Hotel St. George The building was sold to Grahm Junior College in 1968 and was renamed Leavitt Hall. WNAC by this time had moved to brand new studios in Government Center but the college never made use of the radio and television production studios left behind in the basement because of financial reasons. A few years later, the building was sold again. After restorations, the building was renamed "Boston Hotel Buckminster" and has operated as a hotel and apartment building ever since. The Hotel Buckminster has 132 guest rooms and suites. Much of its advertising is based on its relatively low price for a hotel in Boston in very close proximity to attractions including Boston University, Charles River Reservation, the Emerald Necklace, Fenway Park, the Freedom Trail, Hynes Convention Center, the Isabella Stewart Gardner Museum, Lansdowne Street, Newbury Street and the Prudential Center. Kenmore Station, a subway stop on the Green Line that also has an above-ground bus terminal, is located on an adjacent city block and is the hotel's closest MBTA station. In March of 2020 the hotel announced on its Facebook that it was closing due to the COVID-19 pandemic with no plans of reopening under the current management.