From 1966 to 1980 Fraser-Reid was on the faculty of the University of Waterloo in Waterloo, Ontario where he established a research group known as "Fraser-Reid's Rowdies". The primary emphasis of his work at this point was the synthesis of chiral natural products using carbohydrates as the starting materials. In 1975, Fraser-Reid was the first to publish a method for making nonsugar compounds with simple sugars. In 1980, he was hired at the University of Maryland, College Park, and then at Duke University in North Carolina in 1983. In 1985 he was appointed the James B. Duke Professor of Chemistry. At Duke University, his research shifted to exploring the role of oligosaccharides in immune responses, and particularly on the effect of molecules on human diseases like malaria and AIDS. After retiring from Duke in 1996, due to an undisclosed harassment claim, he established the Natural Products & Glycotechnology Research Institute, a nonprofit, to study the carbohydrate chemistry/biology of tropical parasitic diseases in developing countries and to develop a carbohydrate-based malaria vaccine. Fraser-Reid and his team achieved a milestone in oligosaccharide synthesis by assembling a molecule consisting of 28 monosaccharide units.
Achievements
Several sources have reported that Fraser-Reid was nominated in 1998 for a Nobel Prize in chemistry for his work on oligosaccharides and immune responses. This statement cannot be verified since the names of the nominees are never publicly announced, and neither are they told that they have been considered for the Prize. Nomination records are sealed for fifty years. The Institute of Jamaica awarded Fraser-Reid the 2007 Musgrave Medal for his work in chemistry, noting that during his career he co-authored over 330 peer-reviewed publications and supervised 85 post-doctoral fellows and 55 PhD students.
Other interests
Along with his interest in science, Fraser-Reid was an accomplished pianist and organist who gave recitals at notable venues such as St. George's Cathedral, Kingston, Jamaica and Cathedral de Seville, Spain. In the 1970s Fraser-Reid filed a lawsuit against a building contractor who had not followed municipal building codes. The case went all the way to the Supreme Court of Canada where Fraser-Reid prevailed, and "Fraser-Reid v Droumtsekas" is often cited in Canadian civil law.
