Sembrano started with IBC as a newscaster in 1997 before moving to the GMA Network in 1998, where she was the anchor of the first wishing program of the country, Wish Ko Lang. She and GMA had issues with a TV show she was hosting - exposing alleged graft and corruption of a government official - which the network delayed airing but with a certain disclaimer that caused her to walk-out on an evening news cast. GMA terminated her contract on 20 December 2003 but she continued to worked on for Wish ko Lang until 14 February 2004. She was then wooed by the rival ABS-CBN in 2004 where she hosted the public service show "Lukso ng Dugo", an OFW Drama Anthology entitled Nagmamahal, Kapamilya and the morning show Magandang Umaga, Pilipinas. She also served as a correspondent for ABS-CBN's longest investigative journalism show, The Correspondents. She is the current host of Salamat Dok, a weekend current affairs program focusing on medicine and health issues. Sembrano is a co-anchor on TV Patrol, a newscaster on the DZMM radio station programs like Radyo Patrol Balita Alas Dose, Gising Pilipinas with Nelson Lubao, and she anchored Radyo Patrol Alas Kuwatro with Alex Santos when she replaced Jasmin Romero and other news and public affairs programs of ABS-CBN. She is currently anchoring the morning program Lingkod Kapamilya with Julius Babao. And now, Sembrano was back to Umagang Kay Ganda as main anchor/host with Anthony Taberna after a few months when she left the show together with Rica Peralejo, Ginger Conejero and Bekimon. She replaced Pinky Webb, a former main anchor and host of Umagang Kay Ganda who already left the morning show last August 2011. On August 3, 2015, she was named permanent co-anchor of the weekday editions of the said flagship national evening newscast, succeeding Korina Sanchez who left due to Mar Roxas's impending presidential campaign, according to news website medianewser.com. She remains one of the more visible newscasters, television hosts, and correspondents of the ABS-CBN News and Current Affairs.
Personal life
Sembrano owns the B Good Store located inside the Eugenio Lopez, Jr. Communications Center of ABS-CBN. She was formerly the co-owner and founder of a bookstore specializing in hard-to-find books in Quezon City, Philippines. She formed this business partnership with colleagues in Philippine media and former classmates in college. In June 2008, she married Emilio "Orange" Aguinaldo IV, the great-grandson of the first President of the Philippines, Emilio Aguinaldo. In July 2011, she announced that she has Bell's palsy and is undergoing therapy.
