Anti-neurofascin demyelinating diseases

• Chronic inflammatory demyelinating polyneuropathy: Some cases of CIDP are reported to be produced by auto-antibodies against several neurofascin proteins. These proteins are present in the neurons and four of them have been reported to produce disease: NF186, NF180, NF166 and NF155.
• Neuromyelitis optica: NF auto antibodies can also appear in NMO cases. These antibodies are more related to the peripheral nervous demyelination, but they were also found in NMO.
• Multiple sclerosis: Also antibodies against Neurofascins NF-155 can also appear in atypical multiple sclerosis and NF-186 could be involved in subtypes of MS yielding an intersection between both conditions. Around 10% of MS cases are now thought to be anti-NF cases.

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