Curtis was recruited to GlaxoSmithKline in Philadelphia as a Principal Scientist directly after completing her PhD, where she led a small research team researching biomarkers for cardiovascular risk between 2006–2008. In 2008 she was recruited as Scientific Programme Manager for Science Foundation Ireland until 2010 when she was employed as Medical Advisor for Immunotherapeutics with Bristol-Myers Squibb. In 2011, she joined the laboratory of Luke O’Neill in biochemistry at Trinity College Dublin. In 2014, she was awarded an SFI Starting Investigator Research Grant to establish a group studying the impact of clocks on the immune system. Curtis joined the Royal College of Surgeons in Ireland as a research lecturer in Molecular and Cellular Therapeutics in August 2016. Her work has led to the understanding of mechanisms inducing chronic inflammatory diseases like multiple sclerosis which is linked to the disruption of the body clock.
Publications
Curtis, Anne M.; Seo, Sang-beom; Westgate, Elizabeth J.; Rudic, Radu Daniel; Smyth, Emer M.; Chakravarti, Debabrata.; FitzGerald, Garret A.; McNamara, Peter., "HAT-dependent chromatin remodeling and the vascular clock", American Society for Biochemistry and Molecular Biology 2003
Rudic, R Daniel; McNamara, Peter; Curtis, Anne-Maria; Boston, Raymond C.; Panda, Satchidananda; Hogenesch, John B.; FitzGerald, Garret A., "BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis", PLoS Biology 2004; 11: e377
Curtis, Anne M.; Cheng, Yan; Kapoor, Shiv; Reilly, Dermot; Price, Tom S.; FitzGerald, Garret A., "Circadian variation of blood pressure and the vascular response to asynchronous stress", National Academy of Sciences 2007; 104; 3450-3455
FitzGerald, G.A.; Curtis, A.M., "Central and peripheral clocks in cardiovascular and metabolic function", Annals of Medicine 2006; 38: 552-559
Tannahill, G.M.; Curtis, A.M.; Adamik J., Palsson-McDermott, E.M.; McGettrick, A.F.; Goel G.; Frezza, C.; Bernard, N.J.; Kelly, B.; Foley, N.H.; Zheng, L.; Gardet, A.; Tong, Z.; Jany, S.S.; Corr, S.C.; Haneklaus, M.; Caffrey, B.E.; Pierce, K.; Walmsley, S.; Beasley, F.C.; Cummins, E.; Nizet, V.; Whyte, M.; Taylor, C.T.; Lin, H.; Masters S.L.; Gottlieb E.; Kelly V.P.; Clish C.; Auron P.E.; Xavier R.J.; O’Neill L.A.J., "Succinate is an inflammatory signal that induces IL-1β through HIF-1α", Nature, 2013; 496, 238.
Curtis, Anne M.; Bellet, Marina M.; Sassone-Corsi, Paolo; O’Neill, Luke A.J., "Circadian clock proteins and immunity", Immunity 2014; 40: 178-186
Palsson-McDermott, Eva M.; Curtis, Anne M.; Goel, Gautam; Lauterbach, Mario A.R.; Sheedy, Frederick J.;Gleeson, Laura E.; van den Bosch, Mirjam W.M.; Quinn, Susan R.; Domingo-Fernandez, Raquel; Johnston, Daniel G.W.; Jiang, Jian-kang; Israelsen, William J.; Keane, Joseph; Thomas, Craig; Clish, Clary; Vander Heiden, Matthew; Xavier, Ramnik J.; O’Neill, Luke A.J., "Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages", Cell Metabolism 2015; 21: 65-80
Curtis A.M., Early, J.O.; "Immunometabolism: Is it under the eye of the clock?", Seminars in immunology 2016; 28: 478-490
