After completing his Ph.D., Sadgopal returned to India in 1968. He held the post of Fellow at Tata Institute of Fundamental Research, Bombay, during 1968-1971.
Kishore Bharati and the inception of HSTP
In 1971, Sadgopal resigned from TIFR and set up Kishore Bharati, an NGO with its headquarters at Palia Piparia, a village in Hoshangabad district of Madhya Pradesh. The organisation set out to work in the areas of health and agriculture, as well as education. For example, it promoted low-cost irrigation techniques and worked to spread awareness of animal husbandry. It was recognised by UNEP for its environmentally-sound practices. Sadgopal's work in school education began in 1972, with the Hoshangabad Science Teaching Programme. This was a project which aimed to improve the teaching of science in grades 6-8 of government schools in Hoshangabad district. Initially it ran as a pilot project in 16 rural schools, and was jointly managed by Kishore Bharati and another NGO called Friends' Rural Centre. Because of his academic background, Sadgopal was able to rope in scientists from TIFR and other institutions of higher education and research - particularly Delhi University - as members of the core resource group of HSTP. In 1978 the Government of Madhya Pradesh adopted the programme officially and extended it to all middle schools of Hoshangabad district.
Bhopal
With the setting up of Eklavya in 1982, the intervention that began with HSTP entered a new phase, and Sadgopal ceased to be involved in the day-to-day running of HSTP. Following the Bhopal gas leak tragedy in December 1984, he moved on to a different level of activism, working to secure justice for the gas leak victims. He set up a body called Zahreeli Gas Kand Sangharsh Morcha, which organised conferences, rallies etc. When the Acharya Ramamurti Committee was constituted in 1990 to review the National Education Policy of 1980, Anil Sadgopal was nominated as one of the members. However, he resigned from the committee in protest against what he perceived as the government's "backtracking on the goal of universalisation of elementary education".
Delhi
Sadgopal moved to Delhi in 1992. During this period he researched and wrote a book on assassinated trade unionist Shankar Guha Niyogi. In 1994, he joined the University of Delhi as Professor of Education. During 1998-2001, he was Head, Department of Education. He was also Senior Fellow at the Nehru Memorial Museum and Library. From the 1980s, Sadgopal has been increasingly involved in the people's science movement in India. During 1993-2002, he was the National Convener of Bharat Jan Vigyan Jatha, an all India people’s science network.
In 2004, Sadgopal was inducted as a member of the Central Advisory Board of Education, the highest advisory body to the Government in matters related to education. During 2004-2005 he was a member of three CABE committees, including the committee which was to draft the RTE Bill. In July 2005, when the draft was presented at a full meeting of CABE, Sadgopal circulated a note, alleging that the draft prepared by the committee had been changed in a major way, diluting the provisions of the proposed act. The Government dismissed it as his personal view, and he resigned from the committee. Subsequently he has been involved in a campaign to modify the RTE Act and bring in a common school system. He was one of the founders of the All India Forum for Right to Education, set up in 2009, and is a member of its presidium.