Amentoflavone
Amentoflavone is a biflavonoid constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum and Xerophyta plicata.
Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B.
Amentoflavone has a variety of in vitro activities including antimalarial activity, anticancer activity, and antagonist activity at the κ-opioid receptor as well as activity at the allosteric benzodiazepine site of the GABAA receptor as a negative allosteric modulator.
