Alison Goate
Alison M. Goate is a professor of neuroscience and Director of the Loeb Center for Alzheimer's Disease at Icahn School of Medicine at Mount Sinai, New York City. She was previously professor of genetics in psychiatry, professor of genetics, and professor of neurology at Washington University in St. Louis.
The Goate Lab studies the genetics and molecular bases of Alzheimer's disease, frontotemporal dementia, and alcoholism.
Education and early career
After receiving her undergraduate degree in biochemistry at the University of Bristol and her graduate training at Oxford University, Goate studied under Professors Theodore Puck, Professor Louis Lim and Dr. John Hardy. She received a Royal Society University Research Fellowship to conduct research at St. Mary's Hospital Medical School in London.Awards and affiliations
She has received the Potamkin Prize from the American Academy of Neurology, the Zenith Award from the Alzheimer's Association, Senior Investigator Award from the Metropolitan Life Foundation, the St Louis Academy of Science Innovation Award, Carl and Gerty Cori Faculty Achievement Award at Washington University., and a Lifetime Achievement Award from the Alzheimer's Association. She is a fellow of the American Association for the Advancement of Science. She also serves on the faculty of the Hope Center for Neurological Disorders and as an elected member of the National Academy of Medicine.Research
Goate's research centers on the genetics of Alzheimer's disease and related dementias that led to the development of animal and cellular models and the development of anti-amyloid and anti-tau therapies. She has been the principal investigator on four grants and has co-invented and granted six patents.Patents
| Patent Number | Title |
| 8,080,371 | Markers for addiction |
| 6,475,723 | Pathogenic tau mutations |
| 6,300,540 | Transgenic mouse expressing an APP-FAD DNA sequence |
| 6,083,694 | Method for elucidation and detection of polymorphisms, splice variants, and alzheimer'ss S182 gene ns using intronic sequences of the alzheimer's S182 gene |
| 5,973,133 | Mutant S182 genes |
| 5,877,015 | APP770 mutant in alzheimer's disease |
Grants
Partial list:| Funding Source, Project Title & Number | Role in Project | Dates | Direct Costs |
| JPB Foundation Identification of Novel Alzheimer's disease genes using next generation sequencing | Principal Investigator | 9/1/14-8/31/20 | $681,818 |
| NIA Identification and characterization of AD risk networks using multi-dimensional “omics” data NIA U01 AG052411 | Principal Investigator | 7/15/16-5/31/21 | $871,083 |
| Neurodegeneration Consortium- MD Anderson Understanding the mechanism of MS4A-dependent AD risk | Principal Investigator | 08/07/17-08/06/22 | $400,000 |
| NIA Understanding the mechanism of SPI1 dependent Alzheimer disease risk NIA RF1AG054011 | Principal Investigator | 8/01/16-6/30/21 | $498,389 |
Publications
Semantic Scholar lists 483 publications, 22,943 citations and 1,808 influential citations of Goate's peer-reviewed and original contribution as of 2019.Partial list:
- Cited by 5017 as of October 18, 2019.
- Cited by 2274 as of October 18, 2019.
- Cited by 793 as of October 18, 2019
- Cited by 604 as of October 18, 2019.
- Cited by 419 as of October 18, 2019
- Cited by 275 as of October 18, 2019.