Aldosterone-to-renin ratio


Aldosterone-to-renin ratio is the mass concentration of aldosterone divided by the plasma renin activity or by serum renin concentration in blood. The aldosterone/renin ratio is recommended as screening tool for primary hyperaldosteronism.

Interpretation

Aldosterone-to-renin ratio can be given in ng/dL per ng/, that is, nanogram per deciliter of aldosterone per nanogram per of renin. Also, it can be given in pmol/liter per µg/, where aldosterone is given in molar concentration. The former can be converted to the latter by multiplying by 27.6. Also, the inverse value is occasionally given, that is, the renin-to-aldosterone ratio, whose value is the multiplicative inverse of the aldosterone-to-renin ratio.
The cutoff normal individuals from those with primary hyperaldosteronism is significantly affected by the conditions of testing, such as posture and time of day. On average, an ARR cutoff of 23.6 ng/dL per ng/, expressed in alternative units as 651 pmol/liter per µg/, has been estimated to have a sensitivity of 97% and specificity of 94%. An ARR value in an individual that is higher than the cutoff indicates primary hyperaldosteronism.
If the inverse ratio ratio is used, a value lower than the cutoff indicates primary hyperaldosteronism.