* Joseph Allen, delegate to the Massachusetts Constitutional Convention 1788, U.S. Representative from Massachusetts 1810–11. Nephew of Samuel Adams.
* John Quincy Adams, U.S. Minister to the Netherlands 1794–97, U.S. Minister to Prussia 1797–1801, U.S. Minister to Russia 1809–14, U.S. Minister to Great Britain 1815–17, Massachusetts State Senator 1802, U.S. Senator from Massachusetts 1803–08, U.S. Secretary of State 1817–25, President of the United States 1825–29, U.S. Representative from Massachusetts 1831–48, candidate for Governor of Massachusetts 1833. Son of John Adams.
** Charles Allen, Massachusetts State Representative 1830 1833–35 1840, Massachusetts State Senator 1836–37, Judge of Court of Common Pleas in Massachusetts 1842–45, U.S. Representative from Massachusetts 1849–53, delegate to the Republican National Convention 1856, Superior Court Judge in Massachusetts 1859–67. Son of Joseph Allen.
** George Washington Adams, Massachusetts State Representative 1826. Son of John Quincy Adams.
** Edward Everett, U.S. Representative from Massachusetts 1825–35, Governor of Massachusetts 1836–40, U.S. Minister to Great Britain 1841–45, U.S. Secretary of State 1852–53, U.S. Senator from Massachusetts 1853–54, candidate for Vice President of the United States 1860. Brother-in-law of Charles Francis Adams, Sr..
** Charles Francis Adams, Sr., Massachusetts State Representative 1831, Massachusetts State Senator 1835–40, candidate for Vice President of the United States 1848, delegate to the Republican National Convention 1856, U.S. Representative from Massachusetts 1859–61, U.S. Minister to Great Britain 1861–68, candidate for Governor of Massachusetts 1876. Son of John Quincy Adams.
*** John Quincy Adams, Massachusetts State Representative 1866 1869, candidate for Governor of Massachusetts 1867 1868 1869 1870 1871 1879, candidate for Vice President of the United States 1872. Son of Charles Francis Adams, Sr..
*** William C. Lovering, Massachusetts State Senator 1874–75, delegate to the Republican National Convention 1880, U.S. Representative from Massachusetts 1897–1910. Father-in-law of Charles Francis Adams III.
*** William Everett, U.S. Representative from Massachusetts 1893–95, candidate for Governor of Massachusetts 1897. Son of Edward Everett.
*** Brooks Adams, delegate to the Massachusetts Constitutional Convention 1917. Son of Charles Francis Adams, Sr..
*** Henry Cabot Lodge, Massachusetts State Representative 1880, U.S. Representative from Massachusetts 1887–93, U.S. Senator from Massachusetts 1893–1924, delegate to the Republican National Convention 1924. Brother-in-law of Brooks Adams.
**** Charles Francis Adams III, Mayor of Quincy, Massachusetts, 1896–97; delegate to the Massachusetts Constitutional Convention 1917; U.S. Secretary of the Navy 1929–33. Son of John Quincy Adams.
***** Thomas B. Adams, candidate for Democratic nominations for U.S. Senate from Massachusetts 1966, delegate to the Democratic National Convention 1972. Great-grandson of Charles Francis Adams, Sr..
****** William R. Merriam, Minnesota State Representative 1883 1887, Governor of Minnesota 1889–93, delegate to the Republican National Convention 1896. Descendant of John Adams.
****** Eugene H. Nickerson, delegate to the Democratic National Convention 1972, Judge of U.S. District Court 1977. Descendant of John Adams.