Acridone alkaloids
Acridone alkaloids are natural products derived from acridone.Occurrence
Acridone alkaloids are found in bark, wood, leaves and roots of rue plants, especially in roots and suspension cultures of rue.Examples
This group is named after the acridone. Further members are acronycin, melicopicin and rutacridone, among others:
Properties
Many acridone alkaloids are methylated on the nitrogen atom and also have two oxygen functional groups, which can be free, alkylated or incorporated into rings. Acridone alkaloids show a blue-green fluorescence so that they can be detected with UV light. Some alkaloids of this group are effective against malaria pathogens. Furthermore, acronycin inhibits cell division.
