Acid phosphatase


Acid phosphatase is a phosphatase, a type of enzyme, used to free attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphomonoesterase. Acid phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum. This enzyme is present in many animal and plant species.
Different forms of acid phosphatase are found in different organs, and their serum levels are used to evaluate the success of the surgical treatment of prostate cancer. In the past, they were also used to diagnose this type of cancer.
It's also used as a cytogenetic marker to distinguish the two different lineages of Acute Lymphoblastic Leukemia : B-ALL is Acid-Phosphatase negative, T-ALL is acid-phosphatase positive.
, showing acid phosphatase in red at left.
Acid phosphatase catalyzes the following reaction at an optimal acidic pH :
Phosphatase enzymes are also used by soil microorganisms to access organically bound phosphate nutrients. An assay on the rates of activity of these enzymes may be used to ascertain biological demand for phosphates in the soil.
Some plant roots, especially cluster roots, exude carboxylates that perform acid phosphatase activity, helping to mobilise phosphorus in nutrient-deficient soils.
Certain bacteria like Nocardia, can degrade this enzyme and utilize it as a carbon source.

Bone acid phosphatase

may be used as a biochemical marker of osteoclast function during the process of bone resorption.

Genes

The following genes encode the polypeptide components for various acid phosphatase isoenzymes.