ATXN8OS
Ataxin 8 opposite strand, also known as ATXN8OS, is a human gene.Function
SCA8 is an antisense transcript to the KLHL1 gene ; it does not itself appear to be protein coding. A cytidine, thymidine, guanosine trinucleotide repeat expansion that is incorporated into the SCA8 but not the KLHL1 transcript causes spinocerebellar ataxia type 8. When the CTG expansion is present, a polyglutamine mutant protein is produced. Presumably the expansion interferes with normal antisense function of this transcript.
