5F-ADB-PINACA

5F-ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB₁ receptor and CB₂ receptor with EC₅₀ values of 0.24 nM and 2.1 nM respectively.

Metabolism

Twelve 5F-ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included oxidative defluorination followed by carboxylation.

5F-ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act and therefore illegal in Singapore as of May 2015.

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