5-Methoxytryptamine
5-Methoxytryptamine, also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.
5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. It has no affinity for the 5-HT3 receptor and is affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors. Its affinity for the 5-HT5A receptor is unknown.
Measured affinity for some receptors :
- 5-HT1B receptors
- 5-HT1D receptors
- 5-HT1E receptors
- 5-HT1F receptors
- 5-HT2A receptors
- 5-HT2B receptors
- 5-HT2C receptors
- 5-HT4 receptors
- 5-HT6 receptors
- 5-HT7 receptors
