4-HO-MET


4-HO-MET, is a lesser-known psychedelic drug. It is a structural− and functional analog of psilocin as well as the 4-hydroxyl analog of methylethyltryptamine. 4-HO-MET was first synthesized by Alexander Shulgin. In his book TiHKAL, the dosage is listed as 10-20 mg. 4-HO-MET produces psilocin-like distortion of color, sound, and form. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. There have been no reports of deaths from 4-HO-MET, even though people have reported taking doses up to 150 mg, more than an order of magnitude above the effective dose.

Effects

Users report similar effects to psilocin, including mydriasis, closed and open eye visuals, euphoria, time dilation and general change in thought processes. These effects occur in a wavelike pattern such as that of psilocybin with near-normal perception and high effect varying rapidly. The effects last for about 4–6 hours.

Pharmacology

Pharmacokinetics

Binding SitesBinding Affinity Ki
5-HT1A0.228
5-HT2A0.057
5-HT2C0.141
D1>25
D24
D36.7
α1A9.7
α2A2.4
TAAR13.1
H10.82
SERT0.2
DAT>26
NET13

Drug prohibition laws

Sweden

added 4-HO-MET to schedule I as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6 listed as 4-HO-MET 3-etyl]-1H-indol-4-ol.

United Kingdom

4-HO-MET is a class A drug in the UK, as a result of the tryptamine catch-all clause.

United States

4-HO-MET is not scheduled at the federal level in the United States, but it is possible that it could be considered an analog of psilocin, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.