4-Benzylpiperidine


4-Benzylpiperidine is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively. It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor with preference for MAO-A.

Synthesis

can be reacted with toluene to give 4-benzylpyridine. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

Derivatives

  1. Pimetine, a hypolipidemic agent.
  2. Benrixate, an antiarrhythmic agent.
  3. Ifenprodil & Ro-25-6981
  4. TCS 46b
  5. ASS234
  6. JTV-519
  7. JX-401
  8. KW 4099