4-Benzylpiperidine
4-Benzylpiperidine is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively. It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor with preference for MAO-A.
Synthesis
can be reacted with toluene to give 4-benzylpyridine. Catalytic hydrogenation of the pyridine ring then completes the synthesis.Derivatives
- Pimetine, a hypolipidemic agent.
- Benrixate, an antiarrhythmic agent.
- Ifenprodil & Ro-25-6981
- TCS 46b
- ASS234
- JTV-519
- JX-401
- KW 4099