The Blue Dragons were initially deployed to Cam Ranh Bay in September 1965, but in December moved to Tuy Hòa to provide security against the NVA 95th Regiment. In August 1966, the Blue Dragons moved to Chu Lai and was placed under the operational control of the III MAF. Under an arrangement with the USMC, air assets would be provided to the brigade and assigned the same priority for available aircraft as American units. A team from Subunit One, 1st ANGLICO was dispatched and charged with the mission of keeping an air umbrella over the Blue Dragon Brigade in and out of the field. A two-man fire control team was assigned to each ROKMC infantry company at all times. Initially, the AK-47-equipped Vietcong and NVA had somewhat superior small-arms to South Korean soldiers, since they were armed with World War II-era weaponry, although ROK forces like others relied on overwhelming use of heavy artillery and air support against small-arms and mortar units. They soon received more modern weapons from the United States military such as the M16 rifle. Significant operations and actions involving the Brigade include:
Operation Van Buren, a rice harvest security operation with the 101st Airborne Division and ARVN in Phú Yên Province from 19 January to 21 February 1966 results in US claims of 346 VC killed for the loss of 45 ROK and 55 101st Airborne.
Battle of Tra Binh Dong - on 15 February 1967, 11th Company of the Blue Dragons was dug in near the village of Tra Binh Dong in Quảng Nam Province when they were attacked by an estimated 3 VC Battalions supported by heavy mortar and recoilless rifle fire. The VC launched secondary attacks on each flank of the company before attacking with one Battalion against the Company center, breaching the perimeter and using flamethrowers and bangalore torpedoes against the Company's bunkers. The Company counterattacked and with the aid of a South Korean Marine quick reaction company helidropped into the position succeeded in driving back the VC with ROK forces claiming to have killed 243.
Operation Giant Dragon in Quảng Ngãi Province from 17 to 22 February results in ROK claims of 16 VC killed and 61 weapons captured
Operation Dragon Fire in Quảng Ngãi Province from 5 September to 30 October 1967 claims that 541 VC were killed.
Operation Hoang Dieu 101 with III MAF and the ARVN 51st Regiment in Quảng Nam Province from 17 December 1970 to 19 January 1971, unknown casualties
Operation Golden Dragon II, a clear and search operation in Quảng Nam Province from 4 to 21 January 1971
Operation Hoang Dieu 103 with III MAF and the ARVN 51st Regiment in Quảng Nam Province from 3 February to 10 March 1971
The conduct of ROK forces is praised by some South Korean participation in Vietnam states that "the Koreans were thorough in their planning and deliberate in their execution of a plan. They usually surrounded an area by stealth and quick movement. While the count of enemy killed was probably no greater proportionately than that of similar American combat units, the thoroughness with which the Koreans searched any area they fought in was attested to by the fact that the Koreans usually came out with a much higher weaponry count than American forces engaged in similar actions." A total of 320,000 South Koreans served in the Vietnam War, with a peak strength at around 48,000. About 4,000 were killed.