250 BC

By place

Egypt

• Ptolemy II encourages the Jewish residents of Alexandria to have their Bible translated into Greek. Because around seventy translators are used to achieve this, the translation is known as the Septuagint.
• Following the death of the King of Cyrene, Magas, Queen Apama II, Magas' widow, and Antigonus II arrange the marriage of Antigonus' half-brother Demetrius the Fair to Berenice of Cyrene, daughter of Magas and Apama. However, when Demetrius the Fair arrives, Apama becomes his lover. In response, Berenice leads an uprising in which Demetrius is killed in Apama's bedroom.

  Roman Republic

• In the Punic War, the Romans shift their attention to the southwest of Sicily. They send a naval expedition toward the Carthaginian city of Lilybaeum. En route, the Romans seize and burn the Carthaginian held cities of Selinous and Heraclea Minoa. The Romans then begin the siege of Lilybaeum.
• According to tradition, after the defeat of the Carthaginians at the Battle of Panormus, the Carthaginians release Marcus Atilius Regulus from prison and he is sent to Rome on parole to negotiate a peace or an exchange of prisoners. However, on his arrival, he strongly urges the Roman Senate to refuse both proposals and continue fighting. After this he then honours his parole by returning to Carthage where he is executed by being placed in a spiked barrel, which is then let roll down a hill.

  Persia

• Andragoras, a Seleucid satrap of the province of Partahia, tries to gain independence from the Seleucid Kingdom under Antiochus II.

  India

• According to the Theravāda commentaries and chronicles, the Third Buddhist Council is convened by the Mauryan king Ashoka at Pataliputra, under the leadership of the monk Moggaliputta Tissa. Its objective is to purify the Buddhist movement, particularly from opportunistic factions which are being attracted by the royal patronage.
• The Mauryan sculpture Didarganj Yakshi holding a Fly Whisk, from Patna, Bihar in India, is made. It is now kept at the Patna Museum in Patna.
• The Mauryan Lion Capital of Ashoka, is erected as part of a pillar at Sarnath, Uttar Pradesh in India. It is now preserved at the Sarnath Museum in Sarnath.