On March 11, the Eagles traded quarterbackMark Sanchez to the Denver Broncos for a conditional 7th round pick in 2017 NFL Draft— predicated upon Sanchez making the Broncos' Week 1 roster.
On April 20, the Eagles traded their 2016 1st, 3rd, and 4th round picks, along with their 2017 1st round pick and their 2018 2nd round pick to the Cleveland Browns for the 2nd overall pick the 2016 NFL Draft.
The Eagles kicked off the 2016 season against the Cleveland Browns. 2nd Overall pick Carson Wentz made his debut. The Eagles started off well. Wentz threw his 1st career TD to Jordan Matthews. Caleb Sturgis missed a field goal in the 1st Quarter but did made one early in the 2nd Quarter to extend the lead to 10–0. The Browns would respond early in the 2nd quarter with an Isaiah Crowell 1 yard TD to cut the Eagles lead to 10–7. The Eagles only managed to kick another Sturgis field goal in the 2nd Quarter which resulted in a 13–7 lead at halftime. The Browns then kicked another field goal to change the score to 13–10. Midway through the 3rd Quarter, a bad snap by Browns center Cameron Erving went over the head of Quarterback Robert Griffin III and into the end zone for a safety and it extended the Eagles lead to 15–10. Following that drive, Wentz and the offense went back to work. Wentz threw his 2nd TD to Nelson Agholor to change the score to 22–10. The Eagles mainly burned out the clock in the 4th quarter to weaken the Browns hopes of a comeback. Ryan Mathews sealed the game with a 1-yard TD to make the final score 29–10. With the win, the Eagles opened the season 1–0.
Week 2: at Chicago Bears
Following their big win at home, the Eagles trailed to Illinois to square off Jay Cutler and the Bears in Soldier Field. The Bears scored a touchdown early in the 2nd Quarter by Jeremy Langford. The Eagles only got away with 3 field goals throughout the first half leading 9–7 at the half. However, things turned around in the 2nd half. Cutler fumbled early in the 3rd quarter setting up a Ryan Mathews 3 yard touchdown to increase the Eagles lead to 16–7. On the Bears' next drive, Cutler threw an interception to Linebacker Nigel Bradham to set up a touchdown from Carson Wentz to Tight EndTrey Burton to increased their lead to 22–7. Cutler left the game with a thumb injury. Backup Brian Hoyer came to relief him. Early in the 4th quarter, Jeremy Langford fumbled giving the Eagles the ball at the Bears 47 yard line. The Eagles mainly burned out the clock throughout the 4th quarter. Mathews ran for another touchdown to extend their lead to 29–7. Eddie Royal returned a punt for a touchdown with 5 minutes to go in the 4th quarter. However, the Eagles pulled away the game to end their chances. With the win, the Eagles moved to 2-0 and tying the New York Giants for first place in the NFC East.
Week 3: vs. Pittsburgh Steelers
The Eagles returned home to face their long time state rivals, the Pittsburgh Steelers. The Eagles blocked a Chris Boswell field goal to deny 3 points. The Eagles drew first blood with a Caleb Strugis field goal to make the score 3–0. Early in the 2nd quarter, Rookie Quarterback Carson Wentz threw a 12-yard touchdown to Jordan Matthews to add to their lead. The Steelers finally got on board with a Chris Boswell field goal which turned out to be the only scoring play for the Steelers. Strugis notched another field goal to extend their lead to 13–3 at the half. Then, early in the 2nd Half, Wentz threw a 73-yard touchdown to running back Darren Sproles to extend their lead to 20–3. After a Steelers 3 and out, rookie running back Wendell Smallwood scored his first career rushing touchdown and it extend to Eagles lead to 27–3. On the Steelers next drive, veteran quarterback Ben Roethlisberger fumbled the football which the Eagles recovered. The Eagles would score a Kenjon Barner rushing touchdown to create a stunning 31 point lead. The Eagles defense shut down the Steelers offense. Roethlisberger threw an interception to Rodney McLeod late in the game as the Eagles pulled away a huge 34–3 win. With the win, The Eagles headed into their bye week with a commanding 3–0 record and 1st place in NFC East.
After a heartbreaking overtime loss in Dallas, the Eagles traveled to MetLife Stadium to take on the Giants. The Eagles started off slow. Wentz threw 2 interceptions and the defense allowed 2 touchdowns by Eli Manning to Odell Beckham Jr and to Roger Lewis. The Eagles defense struggled all day especially Leodis McKelvin until the 4th quarter when the Eagles intercepted Manning twice. But, they weren't able to comeback as the Eagles failed to score a touchdown. The loss dropped the Eagles to 4–4 and 4th place in the NFC East.
Week 10: vs. Atlanta Falcons
The Eagles, with the win, stay alive in the NFC East and the wild card race as they take down the NFC South leaders and the NFL's best offense.
Week 11: at Seattle Seahawks
Week 12: vs. Green Bay Packers
Week 13: at Cincinnati Bengals
With the loss, the Eagles fell to 5–7. They also fell to 0-4-1 all time in Cincinnati.
Week 14: vs. Washington Redskins
Week 15: at Baltimore Ravens
The loss knocked the Eagles out of playoff contention for the third consecutive year. Despite a rushing touchdown by Carson Wentz in the final seconds, they failed the 2 point conversion; sealing a fifth straight loss and a playoff elimination.
Week 16: vs. New York Giants
After a heartbreaking loss that knocked the Eagles out of the playoffs, they came back home to square off the New York Giants for round 2. Prior to this game, the Eagles were 0–4 against division rivals. Playing with pride, the Eagles knocked off the Giants including a pick 6 by Malcolm Jenkins. With the win, the Eagles snapped their 5-game losing streak and won against the Giants at home for the 3rd consecutive season. The win allowed the Cowboys to clinch the NFC East.
Week 17: vs. Dallas Cowboys
With the win, the Eagles finished the year at 7–9. Furthermore, they won their first game against the Cowboys at Lincoln Financial Field since 2011.
