The Titans switched their primary colored jerseys from light "Titans Blue" to navy blue, the latter of which was the team's primary home jersey color from 1999–2007.
The Titans acquired an additional sixth-round selection in a trade that sent the team's seventh-round selection and linebackerAkeem Ayers to the New England Patriots.
The Titans traded their second-round selection to the New York Giants for the Giants' No. 40, No. 108, and No. 245 overall draft picks.
This was Jameis Winston's first game in the NFL. His first pass attempt was intercepted and returned all the way for a touchdown by Coty Sensabaugh. The Titans would command this game from start to finish and never trailed. With the win, the Titans began their season 1-0.
The Titans lead 27-14 in the third quarter after trailing 14-0 in the first half. In the fourth quarter, it was all Colts as they would outscore the Titans 21-6 in the fourth quarter. The Titans had a chance to tie the game and force overtime late in the fourth quarter, but the 2-point conversion failed, and the Titans lost their 8th straight game against the Colts. With the loss, the Titans fell to 1-2.
Both teams would miss game winning field goals towards the end of regulation. In overtime, Marcus Mariota would lead the Titans down the field and threw the game-winning touchdown to Anthony Fasano to end the game. With the win, the Titans improved to 2-6, earning their first win under Mike Mularkey.
The Titans wore their Nike "color rush" uniforms for this game. With the loss, the Titans fell to 2-8.
Week 12: vs. Oakland Raiders
The Titans would lead 21-17 late in the fourth quarter. However, the Raiders were able to march down the field to win it after Derek Carr threw the go-ahead touchdown to Seth Roberts with 1:21 remaining. The Titans tried to go down the field to try and tie the game, but Mariota threw an interception to Nate Allen with 50 seconds left to seal the game for Oakland. With the loss, the Titans fell to 2-9.
Week 13: vs. Jacksonville Jaguars
The Titans entered this game needing a win to avoid being eliminated from playoff contention. The Titans outlasted the Jaguars 42-39 to improve their record to 3-9, which also improved on their win total from the previous year. This would be their only inter-conference win all season. This would also be their only home win during the season.
With the loss, the Titans fell to 3-12 and finished 1-7 at home for the second straight season.
Week 17: at Indianapolis Colts
The loss ends the Titans season with a losing record of 3-13, tying the Cleveland Browns for the worst record this season, and statistically gives them the right to the top pick in the 2016 NFL Draft. They also lost their 9th straight game against the Colts.
