2015 CAF Champions League knockout stage
The 2015 CAF Champions League knockout stage was played from 26 September to 8 November 2015. A total of four teams competed in the knockout stage to decide the champions of the 2015 CAF Champions League.
Qualified teams
The winners and runners-up of each of the two groups in the group stage qualified for the knockout stage.| Group | Winners | Runners-up |
| A |  TP Mazembe |  Al-Hilal |
| B |  USM Alger | Al-Merrikh |
Format
were played on a home-and-away two-legged basis. If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still level, the penalty shoot-out would be used to determine the winner.Schedule
The schedule of each round was as follows.| Round | First leg | Second leg |
| Semi-finals | 25–27 September 2015 | 2–4 October 2015 |
| Final | 30 October–1 November 2015 | 6–8 November 2015 |
Bracket
In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up, with the group winners hosting the second leg.In the final, the order of legs was determined by a draw, held after the group stage draw.