The qualifying rounds for the 2007–08 UEFA Cup began on 19 July 2007. In total, there were two qualifying rounds which narrowed clubs down to 80 teams in preparation for the first round.
First qualifying round
!colspan="5"|Southern-Mediterranean region !colspan="5"|Central-East region !colspan="5"|Northern region
2-2 on aggregate, Käerjéng win on away goals ---- Liepājas Metalurgs win 3–2 on aggregate ---- SV Ried win 4–3 on aggregate ---- Dinamo Tbilisi win 2–0 on aggregate ---- Mattersburg win 4-3 on aggregate ---- Ekranas win 6-3 on aggregate ---- Drogheda win 4-1 on aggregate ---- 3-3 on aggregate, Haka win on away goals ---- 2-2 on aggregate, Mika win on away goals ---- Groclin win 1-0 on aggregate ---- 2-2 on aggregate, Bełchatów win 4-2 on penalties ---- 3-3 on aggregate, Artmedia Bratislava win on away goals ---- Young Boys win 5-1 on aggregate ---- 2-2 on aggregate, Honvéd win 5-4 on penalties ---- Maccabi Tel Aviv win 4-1 on aggregate ---- Široki Brijeg win 6-3 on aggregate ---- Anorthosis Famagusta win 2-0 on aggregate ---- Rabotnički win 4-2 on aggregate ---- Partizan win 11-1 on aggregate ---- Zlaté Moravce win 4-2 on aggregate ---- Hajduk Split win 2-1 on aggregate ---- Omonia win 4-0 on aggregate ---- Slaven Belupo win 8-4 on aggregate ---- 2-2 on aggregate, Besa Kavajë win on away goals ---- Litex Lovech win 7-0 on aggregate ---- FK Vojvodina win 7-1 on aggregate ---- Dinamo Minsk win 3-1 on aggregate ---- Helsingborg win 9-0 on aggregate ---- 4-4 on aggregate, FC Midtjylland win on away goals ---- Häcken win 2-1 on aggregate ---- OB win 5-0 on aggregate ---- HJK Helsinki win 3-0 on aggregate ---- AIK win 9-0 on aggregate ---- Brann win 14-3 on aggregate ---- Vålerenga win 2-0 on aggregate ---- MYPA win 2-1 on aggregate ---- Sūduva Marijampolė win 4-1 on aggregate
Second qualifying round
!colspan="5"|Southern-Mediterranean region !colspan="5"|Central-East region !colspan="5"|Northern region
Lokomotiv Sofia win 3–1 on aggregate ---- Anorthosis Famagusta win 3–1 on aggregate ---- Rabotnički win 2–1 on aggregate ---- Galatasaray win 4–2 on aggregate ---- União de Leiria win 1–0 on aggregate ---- Sampdoria win 2–1 on aggregate ---- Standard Liège win 4–0 on aggregate ---- Hammarby win 3-2 on aggregate ---- Aalborg BK win 4–2 on aggregate ---- Vålerenga win 7–1 on aggregate ---- Häcken win 2–1 on aggregate ---- Brann win 6–4 on aggregate ---- FC Midtjylland win 7–3 on aggregate ---- OB win 5–1 on aggregate ---- Austria Wien win 5–4 on aggregate ---- Zenit Saint Petersburg win 5–0 on aggregate ---- Rapid Wien win 8–0 on aggregate ---- Blackburn win 3–0 on aggregate ---- Helsingborg win 4–1 on aggregate ---- AIK win 4–3 on aggregate ---- Sion win 4–1 on aggregate ---- Artmedia win 3–2 on aggregate ---- Dnipro win 5–3 on aggregate ---- Hamburg win 4–0 on aggregate ---- Lens win 6–2 on aggregate ---- Groclin win 3–0 on aggregate ---- Litex Lovech win 6–0 on aggregate ---- Erciyesspor win 4–2 on aggregate ---- Atlético Madrid win 5–1 on aggregate ---- Hapoel Tel Aviv win 6–0 on aggregate ---- CSKA Sofia win 3–2 on aggregate ---- Basel win 6–1 on aggregate
