2007–08 UEFA Cup first round


The first round matches of the 2007–08 UEFA Cup were played on 20 September and 4 October 2007, which narrowed clubs down to 40 teams in preparation for the group stage.
!colspan="5"|Group 1
!colspan="5"|Group 2
!colspan="5"|Group 3
!colspan="5"|Group 4
!colspan="5"|Group 5
!colspan="5"|Group 6
!colspan="5"|Group 7
!colspan="5"|Group 8

First leg

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Second leg

Panathinaikos won 5–1 on aggregate.
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Nürnberg 2–2 Rapid București on aggregate. Nürnberg won on away goals.
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Tottenham Hotspur won 7–2 on aggregate.
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Lokomotiv Moscow won 5–1 on aggregate.
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Helsingborg won 8–6 on aggregate.
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Atlético Madrid won 9–0 on aggregate.
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Hamburg won 4–1 on aggregate.
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Zürich won 4–2 on aggregate.
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Austria Wien won 4–2 on aggregate.
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Dinamo București 2–2 Elfsborg on aggregate. Elfsborg won on away goals.
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Aberdeen 1–1 Dnipro Dnipropetrovsk on aggregate. Aberdeen won on away goals.
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Toulouse 1–1 CSKA Sofia on aggregate. Toulouse won on away goals.
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Aalborg BK 2–2 Sampdoria on aggregate. Aalborg BK won on away goals.
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Spartak Moscow won 8–1 on aggregate.
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Sparta Prague 0–0 Odense on aggregate. Sparta Prague won 4–3 on penalties.
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Basel won 8–1 on aggregate.
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Dinamo Zagreb 3–3 Ajax on aggregate. Dinamo Zagreb won on away goals.
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Villarreal won 6–1 on aggregate.
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Panionios won 2–1 on aggregate.
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Zenit Saint Petersburg won 4–1 on aggregate.
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Copenhagen won 3–2 on aggregate.
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AEK Athens won 3–1 on aggregate.
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Hapoel Tel Aviv won 1–0 on aggregate.
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Brann 2–2 Club Brugge on aggregate. Brann won on away goals.
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Bayern Munich won 3–0 on aggregate.
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Galatasaray won 7–4 on aggregate.
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Everton won 4–3 on aggregate.
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Getafe 3–3 Twente on aggregate. Getafe won on away goals.
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Red Star Belgrade won 2–0 on aggregate.
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Rennes won 4–3 on aggregate.
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Palermo 1–1 Mladá Boleslav on aggregate. Mladá Boleslav won 4–2 on penalties.
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Anderlecht won 2–1 on aggregate.
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Fiorentina 2–2 Groningen on aggregate. Fiorentina won 4–3 on penalties.
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Bolton Wanderers won 2–1 on aggregate.
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Aris 2–2 Real Zaragoza on aggregate. Aris won on away goals.
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Larissa won 3–2 on aggregate.
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Bordeaux won 4–3 on aggregate.
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AZ won 1–0 on aggregate.
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Braga won 5–2 on aggregate.
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Bayer Leverkusen won 5–4 on aggregate.