2005–06 Macedonian Second Football League
The 2005–06 Macedonian Second Football League was the fourteenth season since its establishment. It began on 6 August 2005 and ended on 20 May 2006.
Participating teams
| Club | City | Stadium | Capacity |
| Karaorman | Struga | Stadion Gradska Plazha | 500 |
| Lozar | Demir Kapija | Gradski stadion Demir Kapija | 500 |
| Madjari Solidarnost | Skopje | Stadion Boris Trajkovski | 3,000 |
| Metalurg | Skopje | Stadion Zhelezarnica | 3,000 |
| Mladost | Sushica | Stadion Sushica | 1,500 |
| Napredok | Kichevo | Gradski stadion Kichevo | 5,000 |
| Novaci 2005 | Novaci | Stadion Novaci | 500 |
| Pelister | Bitola | Stadion Tumbe Kafe | 8,000 |
| Skopje | Skopje | Stadion Avtokomanda | 4,000 |
| Sloga Jugomagnat | Skopje | Chair Stadium | 6,000 |
| Teteks | Tetovo | Gradski stadion Tetovo | 15,000 |
| Turnovo | Turnovo | Stadion Kukush | 1,500 |
League table
Promotion play-offs
----Relegation playoff
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