The Patriots enjoyed their best season in 2005–2006 when they won a school-record 23 games in the regular season, and for one week were even ranked in the USA Today/ESPN Top 25 for the first time in school history. Head coach Jim Larranaga, who began his stint at George Mason in 1997, also became the CAA's all-time leader in coaching victories and was named the winner of the 2006 Clair Bee Coach of the Year Award on March 31, 2006, and the Virginia Coach of the Year on June 26, 2006, the same day he was nominated for an ESPY award. Although the team lost to Hofstra during the CAA tournament, George Mason were still able to grab an at-large bid in the NCAA tournament. This marks the first time in which the Patriots earned an at-large bid and the first time in 20 years in which the CAA sent two teams to the tournament. The at-large selection of teams from mid-major conferences to the tournament was criticized by media personalities, most notably Billy Packer. In the case of George Mason, this was possibly because of the absence of Tony Skinn, who was suspended for one game by the Patriots for punching Hofstra guard Loren Stokes in the groin during the CAA tournament semifinal loss. Moreover, many believed that Hofstra, who didn't get invited to the tournament despite of the fact that they beat the Patriots twice in a span of ten days, deserved to get in instead of them. Nevertheless, the Patriots entered the tournament as an 11th seed and defeated the 6th seeded Michigan State Spartans, who had played in the previous year's Final Four. In their second round matchup against the defending champion North Carolina Tar Heels, the Patriots were once again underdogs. After falling in a 16–2 hole early in the game, the team was able to bounce back and win the game, 65–60. Their next game was against another mid-major, the Wichita State Shockers. George Mason jumped out to a big early lead, and the Shockers were not able to overcome. The Patriots won, 63–55. Their Elite Eight matchup found themselves facing the Connecticut Huskies, a team that was tabbed as the favorite to win the national championship the entire season. The Patriots were able to defeat the top-seeded Huskies, 86–84 in overtime, in what is recognized as one of the most memorable games in tournament history. Their tournament run would end in Indianapolis, in a Final Four matchup with the Florida Gators, the eventual national champion in both 2006 and 2007. The Patriots were the first team out of the CAA to reach the Final Four and also became the second team to reach it as a double-digit seed. George Mason's Cinderella story ended in Indianapolis, when the eventual National Champion Florida Gators defeated them 73–58 on April 1, 2006. Despite their loss, many sports analysts considered their performance in the 2006 tourney to be the best run by a mid-major in tournament history. In the final rankings of 2005–2006 season, the USA Today/ESPN poll ranked the Patriots eighth in the nation—their highest rank to date. Mason was atypical of recent Final Four teams not only in being a true mid-major, but also in their unusual scoring balance. The Patriots had five players average in double figures, making them one of only six Final Four teams in the 10 seasons from 1998–99 through 2007–08 with that distinction.
