2000 U.S. Men's Clay Court Championships – Singles
was the defending champion, but did not compete this year.
Qualifier Fernando González won the first title of his career by defeating his compatriot Nicolás Massú 6–2, 6–3 in the final.A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
- Andrew Ilie '
- Jan-Michael Gambill '
- Gianluca Pozzi '
- Jason Stoltenberg '
- Paul Goldstein '
- Nicolás Massú '
- André Sá '
- Justin Gimelstob '
Draw
Qualifying
Qualifying Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier