The 1990–91 UEFA Cup was won by Internazionale on aggregate over Roma. This tournament also marked the return of English clubs after a five-year ban resulting from the Heysel Stadium Disaster in 1985. However, for this season only one English club competed in the UEFA Cup from a previous total of four.
Teams
A total of 64 teams participated in the competition, all entering into the [|first round]. Spain, Romania and Denmark gained a slot, while the Soviet Union, Scotland, Austria, France and Yugoslavia lost a slot.
1. FC Magdeburg won 1–0 on aggregate. ---- Roma won 2–0 on aggregate. ---- Aston Villa won 5–2 on aggregate. ---- Dinamo Zagreb 1–1 Atalanta on aggregate. Atalanta won on away goals rule. ---- Bayer 04 Leverkusen won 2–1 on aggregate. ---- Borussia Dortmund won 4–0 on aggregate. ---- Brøndby won 6–4 on aggregate. ---- Vitesse won 1–0 on aggregate. ---- FK Inter Bratislava won 6–2 on aggregate. ---- Chornomorets Odessa won 4–3 on aggregate. ---- Hearts won 4–2 on aggregate. ---- Torpedo Moscow won 5–2 on aggregate. ---- Politehnica Timișoara won 2–1 on aggregate. ---- Fenerbahçe won 6–2 on aggregate. ---- Dundee United won 5–3 on aggregate. ---- GKS Katowice won 4–0 on aggregate. ---- Bordeaux won 2–0 on aggregate. ---- Partizan won 5–0 on aggregate. ---- Köln won 3–1 on aggregate. ---- Valencia won 2–0 on aggregate. ---- Universitatea Craiova won 2–0 on aggregate. ---- Real Sociedad won 3–3 on away goals. ---- FC Lucerne won 3–2 on aggregate. ---- Omonia won 5–4 on aggregate. ---- ---- Anderlecht won 4–0 on aggregate. ---- AS Monaco won 6–2 on aggregate. ---- Sevilla - PAOK 0–0 on aggregate. Sevilla won 4-3 on penalty shoot-out. ---- Internazionale won 4–3 on aggregate. ---- Sporting CP won 3–2 on aggregate. ---- Admira Wacker won 4–0 on aggregate. ---- Bologna won 2–0 on aggregate.
Köln won 2–1 on aggregate. ---- Bordeaux won 2–0 on aggregate. ---- Anderlecht won 4–1 on aggregate. ---- Internazionale won 3–2 on aggregate. ---- Brøndby IF won 4–0 on aggregate. ---- AS Monaco won 1–0 on aggregate. ---- Admira Wacker won 2–1 on aggregate. ---- FC Torpedo Moscow won 4–3 on aggregate. ---- Dortmund won 4–0 on aggregate. ---- Atalanta won 5–1 on aggregate. ---- Bayer Leverkusen won 6–1 on aggregate. ---- Bologna won 4–3 on aggregate. ---- Real Sociedad - Partizan 1-1 on aggregate. Partizan won on penalties. ---- Sporting won 7–2 on aggregate. ---- Roma won 3–2 on aggregate. ---- Vitesse won 5–0 on aggregate.
Third round
First leg
---- ---- ---- ---- ---- ---- ----
Second leg
Atalanta won 2–1 on aggregate. ---- Roma won 7–0 on aggregate. ---- Brøndby IF won 3–0 on aggregate. ---- ---- Internazionale won 4–1 on aggregate. ---- Anderlecht - Borussia Dortmund 2–2 on aggregate. Anderlecht won on away goals ---- Bologna 3–3 Admira-Wacker Wien on aggregate. Bologna won 6–5 on penalties. ---- Sporting CP won 4–1 on aggregate.
Quarter-finals
First leg
---- ---- ----
Second leg
Roma won 6–2 on aggregate. ---- Internazionale won 2–0 on aggregate. ---- Sporting CP won 3–1 on aggregate. ---- Brøndby IF - Torpedo Moscow 1–1 on aggregate. Brøndby IF won on penalties
Semi-finals
First leg
----
Second leg
Roma won 2–1 on aggregate. ---- Internazionale won 2–0 on aggregate.
Partizani
Rapid Wien
R. Antwerp F.C.
Slavia Sofia
AC Omonia
FC Baník Ostrava
Brøndby IF
1. FC Magdeburg
Aston Villa
RoPS
Bordeaux
Iraklis
MTK Hungária FC
FH
Roma
Avenir Beggen
Hibernians FC
FC Twente
Glenavon
Rosenborg
GKS Katowice
Benfica
Derry City
Politehnica Timișoara
Hearts
Chornomorets Odessa
Atlético Madrid
GAIS
Lausanne Sports
Fenerbahçe
Bayer 04 Leverkusen
Dinamo Zagreb