February 12 – Minor league outfielder Gordon Houston becomes the first player in Organized Baseball to die during active duty in World War II. Houston had played with Texarkana in.
March 18 – Jackie Robinson and Nate Moreland request try-outs with the White Sox. Sox manager Jimmie Dykes praises Robinson's baserunning to Pittsburgh Courier sportswriter Herman Hill, saying that "he stole everything but my infielders' gloves." Dykes goes on record to the Courier, saying "Personally, I would welcome Negro players on the White Sox and I believe every one of the other 15 managers would do so likewise. As for the players, they'd all get along too." Ultimately, Dykes is unable to even consider offering contracts to either, stating that it is a matter for club owners, league officials, and the Commissioner of Baseball to allow it.
April–June
June 2 – Ted Williams of the Boston Red Sox enlists in the United States Navy.
May 13 – Jim Tobin of the Boston Braves almost single-handedly beats the Chicago Cubs at Braves Field, 6–5, by pitching a five-hitter and hitting three consecutive home runs. Tobin, who hit a pinch-homer the day before, becomes the only pitcher in modern history to collect three home runs in a Major League game. His fourth at-bat results in a fly ball caught against the fence in left field.
August 23 – Babe Ruth dons a uniform for the first time in 7 years for a hitting exhibition against Walter Johnson at Yankee Stadium. On Johnson's fifth pitch, Ruth hit a drive into the lower right field stands as the crowd thundered its approval. On the final pitch, Ruth hit a towering upper-deck shot that was just foul. He circled the bases doffing his cap and saluting the roaring crowd with every step. Ruth and Johnson then left the field together to a thunderous ovation. $80,000 was raised for the Army-Navy relief fund.
September 11 – Chicago Cubs catcherPaul Gillespie homers in his first major league at bat. In 1945 he will homer in his final major league at bat and become the only player in MLB history to do both.
September 27 – The St. Louis Cardinals clinch the National League pennanton the last day of the regular season by defeating the Chicago Cubs, 9-2, in the first game of a double header at Sportsman's Park, St. Louis. The Cardinals also win Game 2 of the double header and finish the season with a record of 106-48, giving them the most victories by any National League team since Pittsburgh's 110 wins in 1909. Meanwhile, the Brooklyn Dodgers win their season finale, 4-3, against Philadelphia to end the season in second place at 104-50.
October 5 – The St. Louis Cardinals defeat the New York Yankees, 4-2, in Game 5 of the World Series to win their fourth World Championship, four game to one. The loss was the Yankees' first since the 1926 World Series to the Cardinals. They had won eight Series in the interim.
November 1 – The Brooklyn Dodgers name Branch Rickey as the team president, replacing Larry MacPhail who enters the military service. Rickey had resigned as vice-president of the St. Louis Cardinals only three days earlier.
December 1 – At major league meetings in Chicago, World War II travel restrictions are the order of the day. Owners decide to restrict travel to a three-trip schedule rather than the customary four. Spring training in 1943 will be limited to locations north of the Potomac or Ohio rivers and east of the Mississippi.
January 4 – Herold Juul, 48, pitcher for the 1914 Brooklyn Tip-Tops of the Federal League.
January 8 – Harry Pearce, 52, second baseman who played from 1917 through 1919 for the Philadelphia Phillies.
January 22 – Louis Santop, 52, Hall of Fame catcher in the Negro Leagues, an amazing.406 lifetime hitter and the first legitimate home run slugger in black baseball history.
January 31 – Henry Larkin, 82, 19th century first baseman and manager who hit.303 in 10 seasons with the Philadelphia Athletics, Cleveland Infants/Indians and Washington Senators.
January 31 – Ed Phelps, 62, catcher who played with four teams in 11 seasons spanning 1902–1913, and a member of the Pittsburgh Pirates teams who the 1902 and 1903 National League Pennants and played in the 1903 World Series.
February
February 3 – Frank Luce, 45, outfielder who played for the Pittsburgh Pirates in the 1923 season.
February 3 – Happy Finneran, 51, pitcher who played for the Philadelphia Phillies, Brooklyn Tip-Tops, Detroit Tigers and New York Yankees, in a span of five seasons from 1912–1918.
February 7 – Joe Poetz, 41, pitcher who played in two games for the New York Giants in 1926.
February 9 – John Fischer, 86, pitcher who played from 1884 to 1885 with the Philadelphia Keystones and the Buffalo Bisons.
February 16 – Orson Baldwin, 60, pitcher for the 1908 St. Louis Cardinals.
March
March 1 – Bill Delaney, 78, second baseman for the 1890 Cleveland Spiders of the National League.
March 3 – John Buckley, 72, pitcher who played with the Buffalo Bisons of the Players' League in 1890.
March 3 – Clay Fauver, 69, pitcher who played for the Louisville Colonels of the National League in 1899, and also a distinguished college professor and athletic coach both in baseball and football.
March 3 – Dan O'Connor, 73, Canadian first baseman who appeared in six games with the Louisville Colonels club who won the 1890 American Association pennant.
March 4 – Jack Hammond, 51, second baseman who played for the Cleveland Indians in 1915 and divided his playing time with Cleveland and the Pittsburgh Pirates in 1922.
March 5 – Dutch Wetzel, 48, outfielder who played for the St. Louis Browns of the American League in the 1920 and 1921 seasons.
March 12 – Owen Conway, 51, third baseman who played for the Philadelphia Athletics during the 1915 season.
March 13 – Gene Steere, 69, shortstop for the 1894 Pittsburgh Pirates.
March 26 – Jimmy Burke, 67, third baseman for the St. Louis Cardinals from 1903 to 1905 and player-manager of the club for part of 1905, who then moved to the Minor Leagues to manage several teams, returning to the majors to coach for the Detroit Tigers, Boston Red Sox, Chicago Cubs and New York Yankees between 1914 and 1933, while managing the St. Louis Browns from 1918 to 1920.
March 31 – Ray O'Brien, 47, backup outfielder for the 1916 Pittsburgh Pirates.
April
April 3 – John Rudderham, 78, left fielder who appeared in one game with the Boston Reds of the Union Association in its 1884 season.
April 8 – Pat Bohen, 51, pitcher who played from 1913 to 1914 for the Philadelphia Athletics and the Pittsburgh Pirates.
April 11 – Norm McNeil, 49, reserve catcher who played briefly for the Boston Red Sox during the 1919 season.
April 26 – Al Montgomery, 21, catcher who played for the Boston Braves in 1941.
April 26 – Hack Simmons, 57, infielder and outfielder who spent two seasons in the American League with the Detroit Tigers and New York Highlanders, before moving to the outlaw Federal League to play for the Baltimore Terrapins.
May
May 9 – Herm Malloy, 56, pitcher for the Detroit Tigers teams who won the American League pennants in the 1907 and 1908 seasons.
May 15 – Larry Milton, 63, pitcher who played for the St. Louis Cardinals in its 1903 season.
May 20 – Amby McConnell, 59, second baseman who played from 1908 through 1911 for the Boston Red Sox and Chicago White Sox, better known as the player that lined into the first unassisted triple play in Major League Baseball history, and also for setting the Red Sox record for most stolen bases in a single-season by a rookie with 31, which stood until being broken by Jacoby Ellsbury.
May 25 – Bill James, 65, pitcher who played for five teams in all or part of eight seasons between 1911 and 1919, as well as one of the clean members on the 1919 Chicago White Sox club which was made famous by the Black Sox Scandal.
May 26 – Ed Gremminger, 68, third baseman who played for the Cleveland Spiders, Boston Beaneaters and Detroit Tigers in part of four seasons between 1895 and 1904.
May 28 – Charley Bassett, 79, infielder for five National League teams in a span of eight seasons from 1884–1892, who led the league's second basemen in assists in 1887, and fielding percentage in 1887 and 1890.
May 28 – Mike Welday, 63, outfielder who played for the Chicago White Sox in the 1907 and 1909 seasons.
May 30 – Ed Burns, 54, catcher who played from 1912 to 1918 for the St. Louis Cardinals and Philadelphia Phillies.
May 30 – Lee Fyfe, 62, umpire who officiated in the Federal League in 1915 and the National League in 1920.
June
June 1 – Danny Friend, 69, pitcher who played for the Chicago Colts of the National League from 1895 through 1898.
June 26 – Gene Stack, 24, pitcher in the Chicago White Sox Minor League system, who in December 1940 became the first player on a Major League roster to be drafted for World War II service.
June 29 – Manuel Cueto, 50, Cuban outfielder who spent more than 20 years in professional baseball, including stints with the St. Louis Terriers in 1914 and the Cincinnati Reds from 1917 until 1919.
July 1 – Harry Spies, 76, first baseman and catcher who played for the Louisville Colonels and Cincinnati Reds during the 1895 season.
July 17 – Lefty Johnson, 79, outfielder for the Philadelphia Keystones, Indianapolis Hoosiers and Baltimore Orioles in parts of five seasons from 1884–1892.
July 20 – Rap Dixon, 39, All-Star outfielder in the Negro Leagues from 1922 through 1937; a power hitter who could also hit for average as well as one of the fastest players and best defensive outfielders in Negro League history.
July 30 – Jim Baskette, 54, pitcher for the Cleveland Naps from 1911 until 1913.
August
August 3 – Jack Hayden, 61, outfielder who played for the Philadelphia Athletics, Boston Americans and Chicago Cubs in the early 20th century.
October 3 – Pinky Hargrave, 46, catcher for the Washington Senators, St. Louis Browns, Detroit Tigers and Boston Braves between 1923 and 1930.
November
November 8 – Birdie Cree, 60, outfielder who spent his entire career with the New York Highlanders/Yankees from 1908–1915, while hitting.292 in 742 games.
November 14 – Scrappy Carroll, 82, Outfielder for three teams from 1884–1887.
November 15 – Joe Gunson, 79, catcher/outfielder who played four seasons in the majors from 1884, 1889, 1892–1893.
November 24 – Frank Owen, 62, pitcher for the Detroit Tigers and Chicago White Sox from 1901–1908, who posted an 82-67 with a 2,55 ERA.
November 30 – Slim Love, 52, pitcher who posted a 28-21 record with a 3.04 ERA in six seasons with the Senators, Yankees and Tigers.
December
December 5 – Val Picinich, 46, catcher in 1307 games for the Philadelphia Athletics, Washington Senators, Boston Red Sox, Cincinnati Reds, Brooklyn Robins/Dodgers and Pittsburgh Pirates between 1916 and 1933.
December 6 – Amos Rusie, 71, Hall of Fame fireball pitcher whose powerful delivery was the main reason to move the pitching mound in 1893 from 50 feet to its present 60 feet, 6 inches; who retired with a 246-174 record, 1,950 strikeouts and 3.07 ERA in what was really an eight-year career with the New York Giants, collecting 30 or more wins four years in a row and winning 20 or more games eight successive times, while leading the National League in strikeouts five years and leading or tying for most shutouts five times, including a no-hitter, and the Triple Crown in 1894 with a 36-13 mark, 195 strikeouts and a 2.78 ERA en route to a 4–0 four-game sweep of the Baltimore Orioles in the first Temple Cup Championship Series.
