On-campus Ryan Gymnasium, where the Hoyas had played their home games since the 1914-15 season, had no seating, accommodating fans on a standing-room only-basis on an indoor track above the court. This precluded the accommodation of significant crowds, providing the self-sustaining Basketball Association with little revenue with which to fund the teams travel expenses, and Georgetown averaged no more than three road games a year from the 1918-19 season thrtough the 1926-27 season in order to keep travel to a minimum. The 1920-21 teams only road trip outside of Washington was to play schools in Pennsylvania at the end of the season. The Hoyas home winning streak at Ryan Gymnasium reached 34 games at the end of this season, dating back to a victory against Bucknellon the last day of the 1916-17 season; it would reach 52 before finally coming to an end during the 1923-24 season. Highlights of the home season at Ryan included Georgetowns upsets of Georgia Tech and North Carolina, two of the most highly regarded teams in the United States at the time. Georgetown also defeated crosstown rival George Washington twice this season, giving the Hoyas a 14-game winning streak against George Washington - 10 of the wins at Ryan Gymnasium - dating back to 1915. Junior forward Jack Flavin was the teams highest scorer, scoring about a third of the teams points. An excellent shooter, he averaged 12.5 points per gane, and scored a total of 175 points. Junior guard Andrew "Andy" Zazzali played in all 14 games, averaging 4.8 points per game and scoring a total of 65 points. He played an excellent defense during the season; over a stretch of five games that included games against nationally renowned St. John's, North Carolina, and Georgia Tech, his defense played a major role in holding opponents to an average of less than six points in the first half. Sophomore forward Paul Florence was the only new player on the team, which had finished with a 13-1 record the previous season. He was a very accurate shooter, and despite being surrounded by veterans led the team in its season-opening 10-game winning streak. He finished second in scoring, appearing in 12 games, scoring 72 points, and averaging 6.0 points per game for the season. The team won its first 10 games, nine of them at home and one across town against George Washington. It then finished the season by losing all four games on its only road trip to end with a 10-4 record. O'Reilly fell ill after this season and was unable to coach the Hoyas for the next two seasons. He returned to the head coaching position in time for the 1923-24 season.
Roster
Sources Georgetown players did not wear numbers on their jerseys this season. The first numbered jerseys in Georgetown mens basketball history would not appear until the 1933-34 season. Senior forward Bill Dudack later served as the Hoyas head coach during the 1929-30 season.
Sources It was common practice at this time for colleges and universities to include non-collegiate opponents in their schedules, with the games recognized as part of their official record for the season, so the January 24, 1921, game against a United States Army team from Camp A. A. Humphreys in Virginia counted as part of Georgetowns won-loss record for 1920-21. It was not until 1952, after the completion of the 1951-52 season, that the National Collegiate Athletic Association ruled that colleges and universities could no longer count games played against non-collegiate opponents in their annual won-loss records. !colspan=9 style="background:#002147; color:#8D817B;"| Regular Season