1880–81 in English football
The 1880–1881 season was the tenth season of competitive football in England.
International matches
played their first home match outside London when they hosted Wales at Alexandra Meadows in Blackburn.| Date | Venue | Opponents | Score | England scorers | Scotland/Wales scorers |
| 26 February 1881 | Alexandra Meadows, Blackburn | 0–1 | John Vaughan | ||
| 12 March 1881 | Kennington Oval, London | 1–6 | Charles Bambridge | David Hill, Edgar Field, George Ker, Dr John Smith |